Table 2 Integrin αIIbβ3 in tumor cell lines
From: Structure, signal transduction, activation, and inhibition of integrin αIIbβ3
Type of tumors | Cell lines | αIIbβ3 function in tumors | References |
|---|---|---|---|
Breast cancer | MDA-MB-231 | facilitate cell adhesion, migration and invasion | |
Melanoma | A375 | promote adhesion | [139] |
B16 | promote adhesion, and metastasis | [147] | |
M3Dau | induce formation of platelet-tumor aggregates | [148] | |
Lewis lung carcinoma | LL2 | facilitate metastasis | [139] |
Renal cancer | 786-O | facilitate adhesion, migration, proliferation and invasion | [142] |
Colon carcinoma | CT26 | induce tumor cells binding to platelets | [149] |
Ovarian cancer | SKOV-3 | facilitate adhesion, migration, proliferation and invasion | [142] |