Table 1 Clinical characteristics and management by age
Variable | Whole series (n = 1,928) | Patients aged ≥ 65 (n = 928) | Patients aged < 65 (n = 1,000) | p-value (≥ 65 vs. < 65) |
|---|---|---|---|---|
Age (years) | 64.5 (13) | 75.7 (7) | 54.1 (7) | < 0.001 |
Male | 1509 (78.3) | 649 (69.9) | 860 (86) | < 0.001 |
Hypertension | 1113 (57.9) | 657 (70.8) | 456 (45.6) | < 0.001 |
Diabetes | 526 (27.4) | 332 (35.8) | 194 (19.4) | < 0.001 |
Dyslipidaemia | 1055 (54.8) | 539 (58.1) | 516 (51.6) | 0.004 |
Active smoker | 736 (38.3) | 149 (16.1) | 587 (58.7) | < 0.001 |
Peripheral artery disease | 148 (7.7) | 103 (11.1) | 45 (4.5) | < 0.001 |
Prior stroke | 89 (4.7) | 66 (7.1) | 23 (2.3) | < 0.001 |
Prior MIa | 915 (47.5) | 453 (48.8) | 462 (46.2) | 0.251 |
Prior PCIb | 273 (14.2) | 173 (18.6) | 100 (10) | < 0.001 |
Prior stent thrombosis | 33 (1.7) | 18 (1.9) | 15 (1.5) | 0.457 |
Prior heart failure | 49 (2.6) | 39 (4.2) | 10 (1) | < 0.001 |
Prior bleeding event | 31 (1.6) | 21 (2.3) | 10 (1) | 0.028 |
Active neoplasm | 61 (3.2) | 50 (5.4) | 11 (1.1) | < 0.001 |
Total PEGASUS criteria | 1.9 (1) | 2.7 (1) | 1.1 (1) | < 0.001 |
High bleeding risk criteria (%) | 708 (36.7) | 516 (55.6) | 192 (19.2) | < 0.001 |
Creatinine clearance (mL/min) | 88 (38) | 67 (25) | 110 (37) | < 0.001 |
Clinical presentation ACSc | < 0.001 | |||
• Unstable angina | 244 (12.7) | 156 (16.8) | 88 (8.8) | |
• NSTEMId | 728 (38) | 378 (40.7) | 350 (35) | |
• STEMIe | 946 (49.3) | 388 (41.8) | 558 (55.8) | |
Killip class on admission ≥ II | 224 (11.7) | 136 (14.7) | 88 (8.8) | < 0.001 |
Left main or multivessel disease | 1280 (66.5) | 676 (72.8) | 604 (60.4) | < 0.001 |
Number of stents | 1.5 (1.3) | 1.5 (1) | 1.4 (1) | 0.071 |
Total length stents (mm) | 30.2 (20) | 30.7 (20) | 29.9 (19) | 0.372 |
Complete revascularization | 417 (21.9) | 228 (24.6) | 189 (18.9) | 0.002 |
Left ventricle ejection fraction (%) | 55 (10) | 55 (10) | 55 (10) | 0.872 |
In-hospital reinfarction | 21 (1.1) | 8 (0.9) | 13 (1.3) | 0.355 |
In-hospital bleeding | 22 (1.1) | 12 (1.3) | 10 (1) | 0.545 |
P2Y12 inhibitor at discharge | < 0.001 | |||
Clopidogrel | 577 (30.1) | 401 (43.2) | 176 (17.6) | |
Prasugrel | 212 (11.1) | 54 (5.8) | 158 (15.8) | |
Ticagrelor | 1129 (58.9) | 469 (50.5) | 660 (66) | |
DAPTf discontinuatiom | 0.201 | |||
• Before one year | 130 (6.7) | 72 (7.7) | 58 (5.8) | |
• At one year | 1183 (61.4) | 558 (60.1) | 625 (62.5) | |
• Beyond one year | 615 (31.9) | 298 (32.1) | 317 (31.7) |