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Table 2 Variables associated with extended DAPT among patients ≥ 65 years

From: Extended use of dual antiplatelet therapy among older adults with acute coronary syndromes and associated variables: a cohort study

 

Univariate analysis

Multivariate analysis

Variable

Odds ratio (95% CI)

p-value

Odds ratio (95% CI)

p-value

Age*

1.01 (0.99–1.03)

0.289

  

Male

0.87 (0.64–1.18)

0.371

  

Hypertension

1.36 (0.99–1.87)

0.630

  

Diabetes

1.22 (1.05–1.40)

0.008

  

Dyslipidaemia

1.41 (1.06–1.88)

0.019

  

Active smoker

0.95 (0.78–1.14)

0.946

  

Peripheral artery disease

1.43 (0.93–2.19)

0.105

  

Prior stroke

1.48 (0.88–2.49)

0.141

  

Prior MIa

0.81 (0.61–1.07)

0.140

  

Prior PCIb

1.81 (1.28–2.56)

0.001

  

Prior stent thrombosis

7.68 (2.50–23.5)

< 0.001

6.45 (1.72–24.1)

0.006

Prior heart failure

3.58 (1.77–7.27)

< 0.001

3.44 (1.58–7.48)

0.002

Prior bleeding event

0.58 (0.28–1.18)

0.841

  

Active neoplasm

0.70 (0.29–1.68)

0.129

  

Total PEGASUS criteria*

1.22 (1.07–1.39)

0.003

  

High bleeding risk criteria

1.18 (0.89–1.57)

0.239

  

PRECISE DAPT scoring*

1.02 (1.01–1.04)

0.023

  

Creatinine clearance (mL/min)*

0.99 (0.99–1.01)

0.253

  

Left main or multivessel disease

1.99 (1.41–2.82)

< 0.001

1.95 (1.36–2.79)

< 0.001

Number of stents

0.97 (0.86–1.09)

0.601

  

Total length of stents

1.00 (0.99–1.01)

0.290

  

Left ventricle ejection fraction*

1.02 (1.00-1.03)

0.054

1.03 (1.01–1.04)

0.002

Killip class at admission ≥ II

1.49 (1.02–2.20)

0.041

  

In-hospital reinfarction

3.55 (0.84–14.9)

0.084

  
  1. (a) MI: myocardial infarction; (b) PCI: percutaneous coronary intervention
  2. *For quantitative variables, OR reflects the increased probability of extended DAPT as follows: age: per year of increase; PEGASUS criteria: for each additional PEGASUS criteria; PRECISE DAPT scoring: for each integer of increase of PRECISE DAPT value: left ventricle ejection fraction: for each % of increase