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  1. Despite the high frequency with which adverse drug events (ADEs) occur in outpatient settings, detailed information regarding these events remains limited. Anticoagulant drugs are associated with increased saf...

    Authors: Andrea L Long, Lisa Bendz, Monica M Horvath, Heidi Cozart, Julie Eckstrand, Julie Whitehurst and Jeffrey Ferranti
    Citation: Thrombosis Journal 2010 8:5
    Content type: Original clinical investigation Published on:

  2. Postoperative asymptomatic deep venous thromboses (ADVT) can give rise to posttthrombotic syndrome (PTS), but there are still many unresolved issues in this context. For example, there is a lack of knowledge r...

    Authors: Stefan Rosfors, Lena M Persson, Gerd Lärfars and Lasse J Lapidus
    Citation: Thrombosis Journal 2010 8:4
    Content type: Original clinical investigation Published on:

  3. Experimental models of pulmonary embolism (PE) that produce pulmonary hypertension (PH) employ many different methods of inducing acute pulmonary occlusion. Many of these models induce PE with intravenous inje...

    Authors: Michael S Runyon, Michael A Gellar, Nina Sanapareddy, Jeffrey A Kline and John A Watts
    Citation: Thrombosis Journal 2010 8:3
    Content type: Original basic research Published on:

  4. Interaction of fibrinogen with specific leukocyte integrins of monocytes may link coagulation and inflammation, however, the precise mechanism of fibrinogen leading to the pro-inflammatory and pro-coagulatory ...

    Authors: Nicole C Kaneider, Birgit Mosheimer, Andrea Günther, Clemens Feistritzer and Christian J Wiedermann
    Citation: Thrombosis Journal 2010 8:2
    Content type: Original basic research Published on:

  5. The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment eleva...

    Authors: Trygve Brügger-Andersen, Leif Bostad, Dagny Ann Sandnes, AlfInge Larsen, Vernon VS Bonarjee, Ståle Barvik, Tor Melberg and Dennis WT Nilsen
    Citation: Thrombosis Journal 2010 8:1
    Content type: Original clinical investigation Published on:

  6. Hemostasis is a defense mechanism to stop bleeding. Activated by vessel wall injury, it consists of intertwined activation of platelets and the coagulation cascade, tightly controlled by natural anticoagulants...

    Authors: Peter Verhamme and Marc F Hoylaerts
    Citation: Thrombosis Journal 2009 7:15
    Content type: Latest therapeutic developments Published on:

  7. Low molecular weight heparin (LMWH) is in vast usage for treatment of thromboembolic diseases such as deep venous thrombosis and acute coronary syndromes. There are certain clinical situations where a quick po...

    Authors: Ramin Artang, Niels J Frandsen and Jørn Dalsgaard Nielsen
    Citation: Thrombosis Journal 2009 7:14
    Content type: Original basic research Published on:

  8. Myocardial infarction is the combined result of environmental factors and personal predispositions. Prothrombotic factors might play an important role in this phenomenon. Annexin V (ANV) is a calcium-dependent...

    Authors: Mohammad Shojaie, Abdoreza Sotoodah, Shohre Roozmeh, Ensieh Kholoosi and Samira Dana
    Citation: Thrombosis Journal 2009 7:13
    Content type: Original basic research Published on:

  9. Recurrent cardiovascular events following acute myocardial infarction (AMI) are common. The purpose of this study was to evaluate the impact of platelet aggregation, PFA-100 closure times and peak C-reactive p...

    Authors: Angelo Modica, Fredrik Karlsson and Thomas Mooe
    Citation: Thrombosis Journal 2009 7:12
    Content type: Original clinical investigation Published on:

  10. Tissue factor (TF) contributes to thrombosis following plaque disruption in acute coronary syndromes (ACS). Aim of the study was to investigate the impact of plasma TF activity on prognosis in patients with ACS.

    Authors: Birgit A Steppich, Siegmund Lorenz Braun, Andreas Stein, Gabriele Demetz, Philip Groha, Albert Schömig, Nicolas von Beckerath, Adnan Kastrati and Ilka Ott
    Citation: Thrombosis Journal 2009 7:11
    Content type: Original clinical investigation Published on:

  11. Endothelial cell dysfunction, by promoting fibrin deposition, has been implicated in the development of multiple organ failure. Altered fibrinolysis during inflammation may participate in microvascular alterat...

    Authors: Karim Zouaoui Boudjeltia, Sandra Ollieuz, Michael Piagnerelli, Patrick Biston, Philippe Cauchie, Jean-Louis Vincent, Dany Brohee and Michel Vanhaeverbeek
    Citation: Thrombosis Journal 2009 7:10
    Content type: Original clinical investigation Published on:

  12. The Azorean population presents the highest standardized mortality rate for cardiovascular diseases (CVD) when compared to mainland Portugal and other populations. Since thrombosis is a common cause of CVD, we...

    Authors: Claudia C Branco, Tânia Pereirinha, Rita Cabral, Paula R Pacheco and Luisa Mota-Vieira
    Citation: Thrombosis Journal 2009 7:9
    Content type: Original basic research Published on:

  13. The aim of this case report is to describe control of Schamberg's disease using aminaphtone. We report on the case of a 28-year-old patient who presented with multiple purpuric lesions of the lower extremities...

    Authors: José Maria Pereira de Godoy and Fernando Batigália
    Citation: Thrombosis Journal 2009 7:8
    Content type: Case report Published on:

  15. Every year, millions of people undergo percutaneous coronary intervention (PCI) with intracoronary stent implantation. A patient from the PRAGUE-8 trial (Optimal pre-PCI clopidogrel loading: 600 mg before ever...

    Authors: Zuzana Motovska, Petr Widimsky, Iuri Marinov, Robert Petr, Jaroslava Hajkova and Jan Kvasnicka
    Citation: Thrombosis Journal 2009 7:6
    Content type: Case report Published on:

  16. A 27 year-old man who presented to the hospital with progressive lower extremity weakness, developed an acute ST elevation myocardial infarction on his second hospital day. Primary angioplasty to the left ante...

    Authors: Ayyash Melhem, Ankit Desai and Marion A Hofmann
    Citation: Thrombosis Journal 2009 7:5
    Content type: Case report Published on:

  17. Dual anti-platelet therapy with aspirin and a thienopyridine (DAT) is used to prevent stent thrombosis after percutaneous coronary intervention (PCI). Low response to clopidogrel therapy (LR) occurs, but labor...

    Authors: Cosmo Godino, Loredana Mendolicchio, Filippo Figini, Azeem Latib, Andrew SP Sharp, John Cosgrave, Giliola Calori, Michela Cera, Alaide Chieffo, Alfredo Castelli, Attilio Maseri, Zaverio M Ruggeri and Antonio Colombo
    Citation: Thrombosis Journal 2009 7:4
    Content type: Original clinical investigation Published on:

  19. Mild hypothermia is currently standard of care for cardiac arrest patients in many hospitals and a common belief is that hypothermia attenuates platelet aggregation. We wanted to examine the effects of clopido...

    Authors: Carl Högberg, David Erlinge and Oscar Ö Braun
    Citation: Thrombosis Journal 2009 7:2
    Content type: Original basic research Published on:

  20. A 68-year-old woman presented with acute chest pain and a greatly increased platelet count. Cardiac catheterization revealed subtotal occlusion and a thrombus-like filling defect in the right coronary artery. ...

    Authors: Emin Alioglu, Nurullah Tuzun, Fahri Sahin, Buket Kosova, Serkan Saygi, Istemihan Tengiz, Ugur Turk, Nazan Ozsan and Ertugrul Ercan
    Citation: Thrombosis Journal 2009 7:1
    Content type: Case report Published on:

  21. Disturbed cellular cholesterol homeostasis may lead to accumulation of cholesterol in human atheroma plaques. Cellular cholesterol homeostasis is controlled by the sterol regulatory element-binding transcripti...

    Authors: Yue-Mei Fan, Pekka J Karhunen, Mari Levula, Erkki Ilveskoski, Jussi Mikkelsson, Olli A Kajander, Otso Järvinen, Niku Oksala, Janita Thusberg, Mauno Vihinen, Juha-Pekka Salenius, Leena Kytömäki, Juhani T Soini, Reijo Laaksonen and Terho Lehtimäki
    Citation: Thrombosis Journal 2008 6:17
    Content type: Original clinical investigation Published on:

  23. Anticoagulation with warfarin should be stopped 4–6 days before invasive procedures to avoid bleeding complications. Despite this routine, some patients still have high International Normalized Ratio (INR) val...

    Authors: Sam Schulman, Rajae Elbazi, Michelle Zondag and Martin O'Donnell
    Citation: Thrombosis Journal 2008 6:15
    Content type: Original clinical investigation Published on:

  24. Increase in tissue factor (TF) and loss in thrombomodulin (TM) antigen levels has been described in various inflammatory disorders. The functional consequences of such changes in antigen concentrations in the ...

    Authors: Kim Frederix, Ingeborg M Kooter, René van Oerle, Diane Fens, Karly Hamulyak, Miriam E Gerlofs-Nijland, Hugo ten Cate and Henri MH Spronk
    Citation: Thrombosis Journal 2008 6:14
    Content type: Original basic research Published on:

  26. To analyse the effects of rosiglitazone administered at different times on neointimal formation in hypercholesterolemic rabbits following vascular injury.

    Authors: Alexandre Alessi, Olímpio Ribeiro França Neto, Paulo Roberto Slud Brofman, Camila Prim, Lucia Noronha, Ruy Fernando Kuenzer Caetano Silva, Liz Andréa Villela Baroncini and Dalton Bertolim Précoma
    Citation: Thrombosis Journal 2008 6:12
    Content type: Original basic research Published on:

  27. Although cigarette smoking is a well-established risk factor for vascular disease, the genetic mechanisms that link cigarette smoking to an increased incidence of stroke are not well understood. Genetic variat...

    Authors: John W Cole, David W Brown, Wayne H Giles, Oscar C Stine, Jeffrey R O'Connell, Braxton D Mitchell, John D Sorkin, Marcella A Wozniak, Barney J Stern, Mary J Sparks, Mark T Dobbins, Latasha T Shoffner, Nancy K Zappala, Laurie J Reinhart and Steven J Kittner
    Citation: Thrombosis Journal 2008 6:11
    Content type: Original clinical investigation Published on:

  28. Venous thromboembolism (VTE) and thromboembolic arterial diseases are usually considered to be distinct entities, but there is evidence to suggest that these disorders may be linked. The aim of this study was ...

    Authors: Consuelo Huerta, Saga Johansson, Mari-Ann Wallander and Luis AGarcía Rodríguez
    Citation: Thrombosis Journal 2008 6:10
    Content type: Original clinical investigation Published on:

  29. Heparin-induced thrombocytopenia type II (HIT II) is a rare immune-mediated complication of heparin. The diagnosis of HIT is considered in patients exposed to heparin, presenting with thrombocytopenia and thro...

    Authors: Eva Serasli, Maria Antoniadou, Venetia Tsara, Vassilis Kalpakidis, Angelos Megalopoulos, George Trellopoulos, Georgia Papaioannou and Pandora Christaki
    Citation: Thrombosis Journal 2008 6:9
    Content type: Case report Published on:

  30. Neck of femur fractures predispose patients to venous thromboembolism (VTE). NICE has issued guideline 46 to reduce this risk through the use of antithrombic agents. We audited our department's VTE practise by...

    Authors: Radwane Faroug, Shireesha Konnuru, San S Min, Fazleenah Hussain and George Ampat
    Citation: Thrombosis Journal 2008 6:8
    Content type: Original clinical investigation Published on:

  31. Warfarin treatment has a narrow therapeutic range, requiring meticulous monitoring and dosage titration. Individual dosage requirement has recently partly been explained by genetic variation of the warfarin me...

    Authors: Kari BenteFoss Haug, Mohammad N Sharikabad, Marianne K Kringen, Sigrid Narum, Stine T Sjaatil, Per Wiik Johansen, Peter Kierulf, Ingebjørg Seljeflot, Harald Arnesen and Odd Brørs
    Citation: Thrombosis Journal 2008 6:7
    Content type: Original clinical investigation Published on:

  32. Atrial fibrillation affects an estimated 2.5 million Americans and incurs an average annual stroke risk of 4.5% per year. Despite warfarin reducing stroke risk by approximately 66%, prior studies show warfarin...

    Authors: Ajay Srivastava, Michael Hudson, Ihab Hamoud, Joao Cavalcante, Chetan Pai and Scott Kaatz
    Citation: Thrombosis Journal 2008 6:6
    Content type: Original clinical investigation Published on:

  33. The relationship of D-dimer and deep-vein thrombosis (DVT) after total knee arthroplasty (TKA) remains controversial. The purpose of this study was to assess the value of D-dimer in the detection of early DVT ...

    Authors: Chung-Jen Chen, Ching-Jen Wang and Chung-Cheng Huang
    Citation: Thrombosis Journal 2008 6:5
    Content type: Original clinical investigation Published on:

  34. The objective was to evaluate the effects of rosiglitazone on iliac arteries of hypercholesterolemic rabbits undergoing balloon catheter injury in the contralateral iliac arteries.

    Authors: Olímpio Ribeiro França Neto, Dalton Bertolim Precoma, Alexandre Alessi, Camila Prim, Ruy FernandoKuenzerCaetano da Silva, Lucia de Noronha and Liz AndréaVillela Baroncini
    Citation: Thrombosis Journal 2008 6:4
    Content type: Original basic research Published on:

  37. To test the hypothesis that point-of-care assays of platelet reactivity would demonstrate reduced response to antiplatelet therapy in patients who experienced Drug Eluting Stent (DES) ST whilst on dual antipla...

    Authors: Alex R Hobson, Graham Petley, Geraint Morton, Keith D Dawkins and Nick P Curzen
    Citation: Thrombosis Journal 2008 6:1
    Content type: Original clinical investigation Published on:

  39. To prospectively determine the role of platelet glycoprotein IIIa (GP IIIa) gene PlA1/PlA2 polymorphism on the long-term clinical outcome in patients with coronary artery disease undergoing coronary stenting.

    Authors: Claire Le Hello, Rémy Morello, Agnès Lequerrec, Christine Duarte, John Riddell and Martial Hamon
    Citation: Thrombosis Journal 2007 5:19
    Content type: Original clinical investigation Published on:

  41. The true relationship between methylenetetrahydrofolate reductase C677T homozygosity and risk of recurrent spontaneous abortion is unknown, and it is unclear if women with these mutations should be anticoagula...

    Authors: Ivy Altomare, Alan Adler and Louis M Aledort
    Citation: Thrombosis Journal 2007 5:17
    Content type: Original clinical investigation Published on:

  42. Influenza infections have been associated with procoagulant changes. Whether influenza infections lead to an increased risk of pulmonary embolism remains to be established.

    Authors: Matthijs van Wissen, Tymen T Keller, Brechje Ronkes, Victor EA Gerdes, Hans L Zaaijer, Eric CM van Gorp, Dees PM Brandjes, Marcel Levi and Harry R Büller
    Citation: Thrombosis Journal 2007 5:16
    Content type: Original clinical investigation Published on:

  44. Although a number of studies have demonstrated the influence of ABO blood group on plasma levels of von Willebrand factor (VWF), the nature of this association and its clinical importance is still largely unkn...

    Authors: Massimo Franchini, Franco Capra, Giovanni Targher, Martina Montagnana and Giuseppe Lippi
    Citation: Thrombosis Journal 2007 5:14
    Content type: Review Published on:

  45. During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of s...

    Authors: Christoph Sucker, Kai Zacharowski, Matthias Thielmann and Matthias Hartmann
    Citation: Thrombosis Journal 2007 5:13
    Content type: Original clinical investigation Published on:

  46. Oral anticoagulation compromises conventional lupus anticoagulant (LA) screening assays. Mixing studies can counteract the oral anticoagulant effect but the dilution reduces sensitivity and can generate false ...

    Authors: Gary W Moore
    Citation: Thrombosis Journal 2007 5:12
    Content type: Original basic research Published on:

  48. Hyperhomocysteinemia has been described as a risk factor for unexplained recurrent pregnancy loss. Increased levels of homocysteine may be due to inadequate dietary intake of folate and vitamin B12 and inherit...

    Authors: Maristella D'Uva, Pierpaolo Di Micco, Ida Strina, Carlo Alviggi, Mariateresa Iannuzzo, Antonio Ranieri, Antonio Mollo and Giuseppe De Placido
    Citation: Thrombosis Journal 2007 5:10
    Content type: Original clinical investigation Published on:
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