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  1. Review

    Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies

    Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury, platelet accumulation (i.e. adhesion and aggregation) constitutes the first wave of hemostasis. Blood coagulation, ...

    Xiaohong Ruby Xu, Naadiya Carrim, Miguel Antonio Dias Neves, Thomas McKeown, Tyler W. Stratton, Rodrigo Matos Pinto Coelho, Xi Lei, Pingguo Chen, Jianhua Xu, Xiangrong Dai, Benjamin Xiaoyi Li and Heyu Ni

    Thrombosis Journal 2016 14(Suppl 1):29

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  2. Review

    Management of venous thromboembolism: an update

    Venous thromboembolism (VTE), which constitutes pulmonary embolism and deep vein thrombosis, is a common disorder associated with significant morbidity and mortality. Landmark trials have shown that direct ora...

    Siavash Piran and Sam Schulman

    Thrombosis Journal 2016 14(Suppl 1):23

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  3. Review

    DOACs – advances and limitations in real world

    The group of new oral anticoagulants or NOACs, now termed direct oral anticoagulants or DOACs, with their favourable results from large scale phase III clinical trials, represent a major advancement and expand...

    Lai Heng Lee

    Thrombosis Journal 2016 14(Suppl 1):17

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  4. Review

    New horizon in platelet function: with special reference to a recently-found molecule, CLEC-2

    Platelets play a key role in the pathophysiological processes of hemostasis and thrombus formation. However, platelet functions beyond thrombosis and hemostasis have been increasingly identified in recent year...

    Yukio Ozaki, Shogo Tamura and Katsue Suzuki-Inoue

    Thrombosis Journal 2016 14(Suppl 1):27

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  5. Review

    Anti-thrombotic agents derived from snake venom proteins

    Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPI...

    Tur-Fu Huang, Chun-Chieh Hsu and Yu-Ju Kuo

    Thrombosis Journal 2016 14(Suppl 1):18

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  6. Review

    Current animal models of hemophilia: the state of the art

    Hemophilia is the most well-known hereditary bleeding disorder, with an incidence of one in every 5000 to 30,000 males worldwide. The disease is treated by infusion of protein products on demand and as prophyl...

    Ching-Tzu Yen, Meng-Ni Fan, Yung-Li Yang, Sheng-Chieh Chou, I-Shing Yu and Shu-Wha Lin

    Thrombosis Journal 2016 14(Suppl 1):22

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  7. Review

    Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome

    The antiphospholipid syndrome (APS) is an autoimmune disease characterised by a procoagulant state that predisposes to recurrent thrombosis and miscarriages. Two major discoveries have advanced our understandi...

    Fatima El-Assaad, Steven A. Krilis and Bill Giannakopoulos

    Thrombosis Journal 2016 14(Suppl 1):20

    Published on: 4 October 2016

    This article is part of a Supplement: Volume 14 Supplement 1

  8. Review

    Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis

    Disseminated intravascular coagulation (DIC) is a serious disease that, in the presence of underlying disease, causes persistent, generalized, marked coagulation activation. Early treatment based on an appropr...

    Hidesaku Asakura, Hoyu Takahashi, Toshimasa Uchiyama, Yutaka Eguchi, Kohji Okamoto, Kazuo Kawasugi, Seiji Madoiwa and Hideo Wada

    Thrombosis Journal 2016 14:42

    Published on: 28 September 2016

  9. Research

    Disseminated intravascular coagulation with the fibrinolytic phenotype predicts the outcome of patients with out-of-hospital cardiac arrest

    We tested the hypothesis that disseminated intravascular coagulation (DIC) during the early phase of post-cardiopulmonary resuscitation (CPR) is associated with systemic inflammatory response syndrome (SIRS), ...

    Takeshi Wada, Satoshi Gando, Yuichi Ono, Kunihiko Maekawa, Kenichi Katabami, Mineji Hayakawa and Atsushi Sawamura

    Thrombosis Journal 2016 14:43

    Published on: 21 September 2016

  10. Case report

    A case report of asymptomatic aortic thrombosis incidentally detected by computed tomography in apparently healthy subject with a history of cancer surgery

    Aortic thrombosis is a rare disease and only a few cases of the disease, especially associated with chemotherapy for malignant diseases and/or blood diseases, have been previously reported. Although Virchow’s ...

    Tomonori Sugiura, Yasuaki Dohi, Sumiyo Yamashita, Shunsuke Murai and Nobuyuki Ohte

    Thrombosis Journal 2016 14:16

    Published on: 2 August 2016

  11. Review

    Vitamin K antagonist use: evidence of the difficulty of achieving and maintaining target INR range and subsequent consequences

    Vitamin K antagonists (VKAs) are effective oral anticoagulants that are titrated to a narrow therapeutic international normalized ratio (INR) range. We reviewed published literature assessing the impact of INR...

    Jeff R. Schein, C. Michael White, Winnie W. Nelson, Jeffrey Kluger, Elizabeth S. Mearns and Craig I. Coleman

    Thrombosis Journal 2016 14:14

    Published on: 13 June 2016

  12. Research

    Clinical benefit of graduated compression stockings for prevention of venous thromboembolism after total knee arthroplasty: post hoc analysis of a phase 3 clinical study of edoxaban

    Guidelines from the Japanese Circulation Society recommend prophylaxis with anticoagulation plus intermittent pneumatic compression or graduated compression stockings (GCS) among patients at the highest risk f...

    Takeshi Fuji, Satoru Fujita, Tetsuya Kimura, Kei Ibusuki, Kenji Abe, Shintaro Tachibana and Mashio Nakamura

    Thrombosis Journal 2016 14:13

    Published on: 8 June 2016

  13. Research

    Evaluation of the chromogenic anti-factor IIa assay to assess dabigatran exposure in geriatric patients with atrial fibrillation in an outpatient setting

    Dabigatran etexilate may be underutilized in geriatric patients because of inadequate clinical experience in individuals with severe renal impairment and post-marketing reports of bleeding events. Assessing th...

    Luigi Brunetti, Betty Sanchez-Catanese, Leonid Kagan, Xia Wen, Min Liu, Brian Buckley, James P. Luyendyk and Lauren M. Aleksunes

    Thrombosis Journal 2016 14:10

    Published on: 6 May 2016

  14. Original clinical investigation

    Dabigatran etexilate for thromboprophylaxis in over 5000 hip or knee replacement patients in a real-world clinical setting

    Thromboprophylaxis is recommended for patients undergoing total hip or total knee replacement (THR, TKR). An international, open-label, prospective, observational, single-arm study in a routine clinical settin...

    Nadia Rosencher, Charles M. Samama, Martin Feuring, Martina Brueckmann, Eva Kleine, Andreas Clemens and Simon Frostick

    Thrombosis Journal 2016 14:8

    Published on: 1 April 2016

  15. Research

    External validation of prognostic rules for early post-pulmonary embolism mortality: assessment of a claims-based and three clinical-based approaches

    Studies show the In-hospital Mortality for Pulmonary embolism using Claims daTa (IMPACT) rule can accurately identify pulmonary embolism (PE) patients at low-risk of early mortality in a retrospective setting ...

    Erin R. Weeda, Christine G. Kohn, Gregory J. Fermann, W. Frank Peacock, Christopher Tanner, Daniel McGrath, Concetta Crivera, Jeff R. Schein and Craig I. Coleman

    Thrombosis Journal 2016 14:7

    Published on: 14 March 2016

  16. Reviewer acknowledgement

    Reviewer acknowledgment 2015

    The Editors of Thrombosis Journal would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2015) and whose valuable support is fundamental to its success.

    Hugo ten Cate and Yukio Ozaki

    Thrombosis Journal 2016 14:5

    Published on: 24 February 2016

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