Figure 2

Dose dependence of thrombus formation. The extent of platelet adhesion onto the surface, as assessed by the percentage of the collagen-coated surface covered by platelets, is shown as a function of time. Perfusions for shear [100 (■), 1000 (□), 1500 (●), and 2000 (○) s^-1] were performed for 5 minutes (Figure 2A). Perfusions for control (■), insulin [100 (◆) and 1000 pM (◇)] and isoproterenol [100 (▲) and 1000 μM (△)] were performed at 1000 s^-1 (Figures 2B-C) for 6 minutes. The results presented are mean ± s.e.m. of at least 5 experiments using 5 different blood donors.