Table 1 Randomized trials comparing dalteparin or enoxaparin in THR patients

Dechavanne,1989 [17]

D1 = 42

D2 = 41

H = 41

D - 2500 IU SC 2 h pre-op, then q 12 h post-op × 10-13 days

DVT (all)

D1 - 2

D2 - 3

H - 4

D1 - 0

D2 - 0

H - 0

D - 2500 IU SC 2 h pre-op, then q 12 h post-op × 48 h, then 5000 IU q AM × 10-13 days

DVT (proximal)

D1 - 1

D2 - 1

H - 3

H - 5000 IU SC 2 h pre-op, then bid × 2 days post-op, then H dosage was adjusted according to aPTT × 10-13 days

Tørholm, 1991 [16]

D = 60

P = 60

D - 2500 IU SC 2 h pre-op and 12 h post-op, then 5000 IU qAM × 6 days

DVT

D - 9

P - 19

D - 1

P - 0

P - 2 h pre-op and 12 h post-op, then qAM × 6 days

PE

D - 0

P - 1

Dahl, 1997 [19]

D = 134

P = 131

D - 5000 IU SC evening before op and qPM × 7 days, then 5000 IU SC qPM × 28 days (±2 days)

DVT within first 7 days

D - 4

P - 3

D - 0

P - 0

D - 0

P - 0

P - 5000 IU SC evening before op and qPM × 7 days, then placebo × 28 days (±2 days)

DVT within 35 days

D - 22

P - 23

PE within 35 days

D - 0

P - 1

Lassen, 1998 [20]

D = 140

P = 141

D - 5000 IU SC qd, starting 12 h pre-op and × 7 days post-op; then 5000 IU qd × 28 days

DVT (all)

D - 5

P - 12

D - 0

P - 1

D - 0

P - 1

P - 5000 IU SC qd, starting 12 h pre-op and × 7 days post-op; then placebo × 28 days

DVT (proximal)

D - 1

P - 5

PE

D - 0

P - 0

Hull, 2000a [21]

D1 = 504

D2 = 494

W = 500

D1 (pre-op) - 2500 IU SC within 2 h before surgery, then 2500 IUSC 4 or more h after surgery, then 5000 IU SC qAM × 6 days (±2)

DVT (all)

D1 - 36

D2 - 44

W - 81

First 8 days

D1 - 44

D2 - 32

W - 22

D1 - 6

D2 - 4

W - 10

D1 - 2

D2 - 0

W - 2

D2 (post-op) - Placebo within 2 h before surgery, then 2500 IU SC 4 h or more after surgery, then 5000 IU SC qAM × 6 days (±2)

DVT (proximal)

D1 - 3

D2 - 3

W - 11

W - 10 mg PO evening after surgery (5 mg if ≥ 70 years old), then qd dosing by nomogram × 6 days (±2)

PE

D1 - 0

D2 - 0

W - 0

Hull, 2000b [22]

D1 = 199

D2 = 190

W = 180

D (pre-op) - 2500 IU SC within 2 h before surgery, then 2500 IU SC 4 or more h after surgery, then 5000 IU qAM in-hospital, then 5000 IU qd up to 35 days (±2)

DVT (all) out of hospital within first 35 days

D1 - 8

D2 - 6

P - 14

Major bleeds out of hospital within first 35 days

D1 - 0

D2 - 0

P - 0

D1 - 0

D2 - 0

P - 0

D1 - 0

D2 - 0

P - 1

D (post-op) - 2500 IU SC 4 or more h after surgery, then 5000 IU qAM in-hospital; then 5000 IU qd up to 35 days (±2)

DVT (proximal) out of hospital within first 35 days

D1 - 2

D2 - 1

P - 7

W - 10 mg PO evening after surgery (5 mg if ≥ 70 years old or < 57 kg), then qd dosing by nomogram in-hospital, then placebo up to 35 days (±2)

PE out of hospital within first 35 days

D1 - 0

D2 - 0

P - 0

Turpie, 1986 [23]

E = 50

P = 50

E - 30 mg SC bid, started 12-24 h post-op, then qd × 14 days or until discharge

DVT (all)

E - 6

P - 21

E - 1

P - 2

E - 0

P - 1

P - 30 mg placebo SC bid started 12-24 h post-op, then × 14 days or until discharge

DVT (proximal)

E - 2

P - 10

PE

E - 0

P - 0

Planes, 1988 [24]

E = 124

H = 113

E - 40 mg SC starting 12 h (the day before surgery) pre-op, then qd × 14 days or until discharge

DVT (all)

E - 15

H - 27

E - 2

H - 0

E - 0

H - 0

H - 5000 IU SC starting 2 h (on the day of surgery) pre-op, then tid × 14 days or until discharge

DVT (proximal)

E - 9

H - 20

PE

E - 2

H - 3

Levine, 1991 [25]

E = 333

H = 332

E - 30 mg SC bid, starting 12-24 h post-op, then bid × 14 days or until discharge

DVT (all)

E - 57

H - 63

E - 11

H - 19

E - 0

H - 2

E - 0

H - 0

H - 7500 IU SC bid, starting 12-24 h post-op, then bid × 14 days or until discharge

DVT (proximal)

E - 16

H - 18

PE

E - 0

H - 1

Colwell, 1994 [26]

E1 = 195

E2 = 205

H = 210

E1 - 30 mg SC q 12 h × 7 days E2 - 40 mg SC qdx 7 days H - 5000 IU SC q 8 h × 7 days

DVT (all)

E1 - 9

E2 - 30

H - 24

E1 - 8

E2 - 3

H - 13

E1 - 7

E2 - 3

H - 5

E1 - 1

E2 - 0

H - 2

DVT (proximal)

E1 - 4

E2 - 8

H - 10

PE

E - 0

H - 3

Avikainen, 1995 [27]

E = 83

H = 84

E - 40 mg SC qd, starting 12 h pre-op, then qd × 10 days

DVT (all/proximal)

E - 1

H - 4

E - 7

H - 7

H - 5000 IU SC bid, starting 2 h pre-op and 12 h post-op, then bid × 10 days

PE

E - 0

H - 1

Bergqvist,1996 [28]

E = 131

P = 131

E - 40 mg SC qd starting 12 h pre-opx 7-11 days then 40 mg SC qd post-op × 21 days

DVT (all)

E - 21

P - 45

E - 1

P - 0

E - 0

P - 0

E P - 40 mg SC qd starting 12 h pre-op × 7-11 days then placebo qd post-op up to 21 days

DVT (proximal)

E - 8

P - 28

PE

E - 0

P - 2

Planes, 1996 [29]

E = 90

P = 89

E - 40 mg SC qd × 21 days P - qd × 21 days

DVT (all)

E - 6

P - 17

E - 0

P - 0

E - 0

P - 0

E - 0

P - 0

DVT (proximal)

E - 5

P - 7

PE

E - 0

P - 0

Rader, 1998 [30]

E = 70

H = 56

E - 5000 IU SC PM pre-op and AM and PM op day, then post-op enoxaprin 40 mg SC qd × 13-21 days

DVT (all)

E - 2

H - 1

E - 0

H - 0

H - 5000 IU SC PM pre-op and AM and PM op day, then 5000 IU SC tid × 3 days, then 7500 IU tid on 4th day post-op × 13-21 days

PE E - 0 H - 0

Comp, 2001 [31]

E = 224

P = 211

E - 30 mg SC bid, starting 12-24 h post-op and continuing 7-10 days; then enoxaparin 40 mg SC qd × 18-21 days

DVT (all)

E - 18

P - 49

E - 0

P - 0

E - 3

P - 2

P - enoxaparin 30 mg SC bid, starting 12-24 h post-op and continuing 7-10 days; then placebo qd × 18-21 days

DVT (proximal)

E - 6

P - 27

PE

E - 0

P - 1

Senaran, 2006 [32]

E = 50

H = 50

E - 40 mg SC qd, starting 12 h pre-op × 7-10 days until discharge

DVT during hospitalization (first 7-10 days)

E - 0

H - 2

E - 2

H - 0

E - 0

H - 0

E - 0

H - 0

H - 5000 IU SC, starting q 8 h pre-op, then continued to 15,000 IU qd in 3 equal doses q 8 h × 7-10 days until discharge

DVT within 45 days after discharge

E - 2

H - 0

* 45 day post discharge follow up

PE

E - 0

H - 0

Fuji, 2008 [33]

E1 = 104

E2 = 105

E3 = 107

P = 105

E1 - 20 mg SC qd, started 24-26 h post-op, then qd × 14 days

DVT (all)

E1 - 21

E2 - 18

E3 - 27

P - 36

E1 - 1

E2 - 3

E3 - 2

P - 0

E2 - 20 mg SC bid, started 24-26 h post-op then qd × 14 days

E3 - 40 mg SC qd, started 24-26 h post-op, then qd × 14 days

DVT (proximal)

E1 - 3

E2 - 3

E3 - 6

P - 9

P - qd × 14 days

*Follow-up at 90 days after surgery

PE

E1 - 0

E2 - 0

E3 - 0

P - 0