Target | Factor IIa | Factor Xa | Factor Xa | Factor Xa |
Half-life (hour) | 12-17 | 5-9 | 12 | 6-10 |
Time to peak effect (hour) | 1-3 | 2-4 | 1-3 | 1-2 |
Renal clearance as unchanged drug (%) | 80 | 33 | 27 | 50 |
Drug Interactions Pathways | P-gp | 3A4/P-gp | 3A4/P-gp | 3A4/P-gp |
Dosing in non-valvular AF | 150 mg BID | 20 mg OD | 5 mg BID | 60 mg OD |
Dosing in VTE treatment | 150 mg BID after 5-10 days of parenteral anticoagulation | 15 mg BID for 21 days followed by 20 mg OD | 10 mg BID for 7 days followed by 5 mg BID | 60 mg OD after 5 days of parenteral anticoagulation |