Table 3 Mean plasma concentrations of coagulation biomarkers at various time points after total knee or total hip arthroplasty in patients with and without VTE
Preoperation | Pretreatment | Day 7a | End of treatment (days 11–14)a | ||||||
|---|---|---|---|---|---|---|---|---|---|
n | Mean (SD) | n | Mean (SD) | n | Mean (SD) | n | Mean (SD) | ||
Patients without VTE | |||||||||
D-dimer (μg/mL) | Edoxaban | 526 | 0.73 (0.84) | 526 | 9.33 (12.54) | 521 | 4.40 (2.09) | 511 | 5.35 (2.49) |
Enoxaparin | 485 | 0.77 (0.94) | 485 | 10.28 (14.82) | 443 | 5.38 (2.32) | 430 | 6.00 (2.96) | |
F1+2 (pmol/L) | Edoxaban | 526 | 273.6 (150.3) | 526 | 478.6 (748.6) | 521 | 361.5 (164.6) | 511 | 293.5 (169.3) |
Enoxaparin | 485 | 273.9 (139.3) | 485 | 614.6 (3357.3) | 443 | 457.9 (183.8) | 430 | 372.6 (166.6) | |
SFMC (μg/mL) | Edoxaban | 526 | 5.38 (17.34) | 526 | 31.21 (39.32) | 521 | 5.55 (9.04) | 511 | 6.31 (11.22) |
Enoxaparin | 485 | 4.33 (6.04) | 485 | 31.87 (43.53) | 443 | 6.22 (11.68) | 430 | 6.94 (10.80) | |
Patients with VTE | |||||||||
D-dimer (μg/mL) | Edoxaban | 28 | 0.75 (0.86) | 28 | 8.40 (9.17) | 24 | 4.56 (1.52) | 23 | 5.46 (2.88) |
Enoxaparin | 58 | 0.90 (0.97) | 58 | 16.96 (24.17) | 47 | 7.06 (3.86) | 49 | 8.41 (3.78) | |
F1+2 (pmol/L) | Edoxaban | 28 | 258.4 (117.4) | 28 | 483.3 (220.5) | 24 | 352.9 (128.3) | 23 | 248.7 (86.31) |
Enoxaparin | 58 | 309.8 (273.2) | 58 | 824.8 (959.3) | 47 | 531.2 (213.6) | 49 | 444.5 (222.0) | |
SFMC (μg/mL) | Edoxaban | 28 | 8.90 (21.23) | 28 | 52.19 (48.89) | 24 | 8.10 (18.70) | 23 | 4.77 (2.38) |
Enoxaparin | 58 | 8.36 (18.17) | 58 | 63.67 (56.12) | 47 | 12.31 (26.32) | 49 | 9.85 (17.73) | |