Table 4 Mean plasma concentrations of coagulation biomarkers at various time points after total knee or total hip arthroplasty in patients with and without major or clinically relevant nonmajor bleeding
Preoperation | Pretreatment | Day 7a | End of treatment (days 11–14)a | ||||||
|---|---|---|---|---|---|---|---|---|---|
n | Mean (SD) | n | Mean (SD) | n | Mean (SD) | n | Mean (SD) | ||
Patients without major or CRNM bleeding | |||||||||
D-dimer (μg/mL) | Edoxaban | 627 | 0.75 (0.99) | 627 | 9.75 (12.95) | 597 | 4.43 (2.07) | 578 | 5.38 (2.49) |
Enoxaparin | 626 | 0.78 (0.92) | 626 | 10.72 (15.39) | 552 | 5.47 (2.53) | 517 | 6.15 (3.00) | |
F1+2 (pmol/L) | Edoxaban | 627 | 275.4 (148.0) | 627 | 484.7 (736.0) | 597 | 361.1 (162.2) | 578 | 291.7 (163.2) |
Enoxaparin | 626 | 276.4 (153.3) | 626 | 617.3 (2975.3) | 552 | 463.4 (192.4) | 517 | 378.2 (171.4) | |
SFMC (μg/mL) | Edoxaban | 627 | 5.72 (17.49) | 627 | 32.69 (40.46) | 597 | 5.66 (9.50) | 578 | 6.30 (11.18) |
Enoxaparin | 626 | 4.80 (8.14) | 626 | 34.71 (45.40) | 552 | 6.88 (13.49) | 517 | 7.12 (11.43) | |
Patients with major or CRNM bleeding | |||||||||
D-dimer (μg/mL) | Edoxaban | 30 | 0.52 (0.27) | 30 | 8.73 (11.84) | 15 | 4.53 (1.70) | 9 | 6.29 (3.52) |
Enoxaparin | 24 | 0.89 (1.29) | 24 | 8.95 (9.28) | 14 | 5.24 (1.86) | 10 | 8.40 (6.20) | |
F1+2 (pmol/L) | Edoxaban | 30 | 264.5 (108.3) | 30 | 440.3 (430.4) | 15 | 371.5 (141.5) | 9 | 325.0 (140.9) |
Enoxaparin | 24 | 265.8 (113.4) | 24 | 526.2 (714.4) | 14 | 470.3 (143.3) | 10 | 449.0 (120.6) | |
SFMC (μg/mL) | Edoxaban | 30 | 3.41 (1.82) | 30 | 30.28 (44.24) | 15 | 4.03 (1.06) | 9 | 6.42 (3.20) |
Enoxaparin | 24 | 5.05 (4.38) | 24 | 26.66 (32.86) | 14 | 4.08 (1.49) | 10 | 7.84 (4.31) | |