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Table 4 Age-stratified changes in coagulation markers during head-up tilt among 178 patients with unexplained syncope

From: Procoagulatory changes induced by head-up tilt test in patients with syncope: observational study

 

Age < 65 years

p-value*

Age ≥ 65 years

p-value*

N (%)

119 (67)

 

59 (33)

 

Δ FVIII:C (kIE/L)

0.02 ± 0.15

0.17

−0.01 ± 0.15

0.55

Δ VWF:Ag (kIE/L)

0.04 ± 0.15

0.006

0.10 ± 0.19

<0.001

Δ VWF:GP1bA (kIE/L)

0.02 ± 0.22

0.35

0.02 ± 0.19

0.37

Δ Fibrinogen (g/L)

0.10 ± 0.30

<0.001

0.07 ± 0.20

0.009

Δ LA1 (sec)

−0.40 ± 2.88

0.14

−0.31 ± 1.92

0.25

Δ APC-resistance

−0.16 ± 0.24

<0.001

−0.24 ± 0.28

<0.001

Δ APTT/C+ (sec)

−8.5 ± 12.2

<0.001

−10.6 ± 11.9

<0.001

Δ APTT/C- (sec)

−1.3 ± 2.1

<0.001

−1.3 ± 2.0

<0.001

  1. *supine vs. HUT paired samples t-test; FVIII, factor VIII; VWF:Ag, von Willebrand factor antigen; vWF:GP1bA, von Willebrand factor GP1bA activity; LA1, lupus anticoagulant-screening; APC-resistance, activated protein C resistance; APTT, activated prothrombin time; C+/−, with/without activated protein C