Table 1 Baseline characteristics of patients with acute leukemia

Sex

0.314

0.151

0.280

0.398

 -Female

125 (47.9%)

29 (41.4%)

14 (58.3%)

82 (49.1%)

 -Male

136 (52.1%)

41 (58.6%)

10 (41.7%)

85 (50.9%)

Median age (IQR) (years)

49 (35–61)

35 (22–58)

43 (34–48)

55 (40–63)

 < 0.001

0.336

 < 0.001

0.001

Clinical features of major bleeding (WHO grade 4)

 -Oropharyngeal

4 (1.5%)

4 (5.7%)

0 (0%)

0 (0%)

 -Epistaxis

3 (1.1%)

2 (2.9%)

0 (0%)

1 (0.6%)

 -Hemoptysis

5 (1.9%)

1 (1.4%)

1 (4.2%)

3 (1.8%)

 -UGIB

7 (2.7%)

2 (2.9%)

0 (0%)

5 (3.0%)

 -LGIB

6 (2.3%)

3 (4.3%)

0 (0%)

3 (1.8%)

 -Hematuria

4 (1.5%)

3 (4.3%)

1 (4.2%)

0 (0%)

 -Vaginal bleeding

4 (1.5%)

1 (1.4%)

2 (8.2%)

1 (0.6%)

 -Muscle hematoma

1 (0.4%)

0 (0%)

1 (4.2%)

0 (0%)

 -Retinal hemorrhage

8 (3.1%)

5 (7.1%)

0 (0%)

3 (1.8%)

 -Intracerebral hemorrhage

8 (3.1%)

1 (1.4%)

2 (8.3%)

5 (3.0%)

 -Overall bleeding events (numbers of patients)

50 (44 patients)

22 (18 patients)

7 (6 patients)

21 (20 patients)

0.019

0.945

0.009

0.107

Clinical features of thrombosis

 -Deep vein thrombosis

2 (0.8%)

0 (0%)

0 (0%)

2 (1.2%)

 -Pulmonary embolism

5 (1.9%)

1 (1.4%)

2 (8.3%)

2 (1.2%)

 -Acute arterial occlusion

1 (0.4%)

0 (0%)

1(4.2%)

0 (0%)

 -Splenic infarction

2 (0.8%)

0 (0%)

0 (0%)

2 (1.2%)

 -Acute cerebral infarction

7 (2.7%)

2 (2.9%)

0 (0%)

5 (3.0%)

 -Overall thrombotic events (numbers of patients)

17 (16 patients)

3 (3 patients)

3 (2 patients)

11 (11 patients)

0.719

0.599

0.763

0.670

Laboratory at diagnosis

 Mean ± SD

  -Hemoglobin (g/L)

78 ± 23

87 ± 24

84 ± 23

74 ± 21

 < 0.001

0.582

 < 0.001

0.035

 Median (IQR)

  -WBC (× 10⁹/L)

18.50 (3.96–95.50)

26.72 (4.30–116.63)

4.66 (1.20–26.09)

18.27 (4.52–86.31)

0.012

0.008

0.476

0.005

  -Platelet (× 10⁹/L)

40.00 (18.00–81.00)

50.50 (21.00–94.00)

33.00 (20.00–49.00)

37.00 (16.00–73.00)

0.297

0.151

0.210

0.554

  -PT (seconds)

14.0 (13.0–15.6)

13.6 (12.5–15.3)

14.1 (13.4–16.8)

14.0 (13.1–15.6)

0.189

0.130

0.127

0.467

  -APTT (seconds)

26.1 (23.8–29.4)

26.9 (23.9–28.9)

25.5 (23.8–30.2)

25.8 (23.5–29.5)

0.928

0.745

0.725

0.976

  -Fibrinogen (mg/dL)

349 (247–453)

338 (219–436)

153 (123–287)

372 (272–484)

 < 0.001

 < 0.001

0.044

 < 0.001

  -D-dimer (µg FEU/L)

3,259.1 (1,120.0–8,492.5)

4,034.7 (1,338.6–9,145.9)

9,308.5 (5,490.2–10,000.0)

2,394.4 (967.5–6,502.0)

 < 0.001

0.001

0.057

 < 0.001

Median ISTH-DIC scores

3 (2–5)

3 (1–5)

5 (4–6)

3 (2–4)

 < 0.001

0.001

0.479

 < 0.001

Numbers of overt DIC

75 (28.7%)

20 (28.6%)

15 (62.5%)

40 (24.0%)

 < 0.001

0.003

0.456

 < 0.001