Table 2 Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the ISTH-DIC score to predict bleeding and thrombotic complications
Logistic model | Cutoff | Number of overall events (%) | Bleeding or thrombotic events N (%) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Accuracy (95% CI) |
|---|---|---|---|---|---|---|---|---|
ISTH-DIC score |  ≥ 4 | 86 (40.0) | 27 (58.7) | 58.7% | 60.0% | 23.9% | 87.2% | 59.8% |
(bleeding) |  < 4 | 129 (60.0) | 19 (41.3) | (43.2–73.0) | (53.1–66.6) | (16.4–32.8) | (80.7–92.1) | (53.8–65.7) |
ISTH-DIC score (bleeding) |  ≥ 5 | 55 (25.6) | 20 (43.5) | 43.5% | 74.4% | 26.7% | 86.0% | 68.9 |
 < 5 | 160 (74.4) | 26 (56.5) | (28.9–58.9) | (68.0–80.1) | (17.1–38.1) | (80.2–90.7) | (63.4–74.58) | |
ISTH-DIC score |  ≥ 4 | 104 (42.4) | 9 (56.2) | 56.3% | 57.6% | 8.0% | 95.3% | 57.5% |
(thrombosis) |  < 4 | 141 (57.6) | 7 (43.8) | (29.9–80.2) | (51.1–63.8) | (3.7–14.6) | (90.5–98.1) | (51.5–63.5) |
ISTH-DIC score |  ≥ 5 | 69 (28.2) | 6 (37.5) | 37.5% | 71.8% | 8.0% | 94.6% | 69.7% |
(thrombosis) |  < 5 | 176 (71.8) | 10 (62.5) | (15.2–64.6) | (65.8–77.4) | (3.0–16.6) | (90.3–97.4) | (64.2–75.3) |