Table 5 Systematic review of the literature for outcomes of neonatal portal vein thrombosis in the management and follow-up management (2010–2022)

Gharehbagi MM et al.-2011-(8 ) 5 − 4 (%80)

UVC related

0 3 CR/2 Death

(3–6 weeks)

Mean GA:30 weeks

%80 UVC

Morag L et al.-2011-(9) 133 − 95(%74)

UVC related

59(%44 ACT) Not stated

Only 70 patients

followed median of 55

months (range,

24–96). 14 (20%)

normal; 2 (3%) PHT;

18 (26%) LLA; 5 (7%)

splenomegaly.

Korber F et al.-2011-(10) 14 − 1 (%7)

UVC related

2(%16 ACT) 1 CR with ACT,

1 recanalized

spontaneous

14 (6 term; 8 preterm

[24–35 weeks]);

13 occlusive, 1

nonocclusive.

11untreated had

increased liver arteries.

Hery G et al.-2013-(11) 3- UVC unrelated

1(%33 surgical) Not stated

3 cases GA: a34 weeks

,†37 weeks, ‡39 weeks

(all occlusive). None

UVC related.

iAt 9 years: portal

cavernoma, PHTN,

splenomegaly †

At 9 years: portal

cavernoma, PHTN,

esophageal varices

At 2.5 years: normal

portal flow.

Pergantau H et al.-2014-(12) 7- UVC unrelated

4(%57ACT) 5CR(4 treated,1

Spontaneous)

At median of 6 years

:5 (71%) CR (4 treated;

1 untreated); 1

(14%, untreated)

PHTN; 1 (14%,

untreated) esophageal

varices

Rios Mendez RE et al.-(13) 1- UVC related

1(%100 ACT) CR

Follow-up for 2.5

months and reported

normal

Himami F et al.-2014-(14) 1- UVC unrelated

0 Not stated

At 18 months: portal

cavernoma persisted

Cakir U et al.-2015-(15) 1-UVC related

1(UFH/LMWH CR

for 8 weeks)

1 term infant.

Nonocclusive, post

TAPVR surgery. At 6

months: No portal

venous thrombosis or

PHTN

Rambaund G et al.-2015-(16) 1- UVC related

0 CR

1 case. 34 weeks;

nonocclusive; UVC

related; associated

Tetralogy of Fallot

Gluffre M et al.-2016-(17) 1- UVC related

1(LMWH for CR

1 month)

32 weeks GA appears

occlusive but not stated.

At 1 year: PR

Salih CC et al. -2020-(18) 13- (5 complet and

8 partial occlusion)

13 13 CR (7–120 days

(LMWH for 31 ± 13.8 days)

Mean GA: 29 ± 2 weeks

No additional data for

follow ups.