Preventive strategies for hypercoagulation in Cushing’s syndrome: when and how

Thrombosis Journal

Table 2 Clinical studies regarding thromboprophylaxis strategies implemented in the context of endogenous hypercortisolism

Author, year	Etiology of CS	Patients (n)	Thromboprophylaxis strategy	Incidence of postoperative VTE
Boscaro M et al., 2002¹³	61% CD 19% ACA 8% ACC	75	No anticoagulation	20%
Boscaro M et al., 2002¹³	65% CD 15% ACA 7% ACC	232	Non-fractioned heparin followed by warfarin	6%
Barbot M et al., 2015⁵	100% CD	34	LMWH during 14 days plus universal GC coverage	8.8%
Barbot M et al., 2015⁵	100% CD	44	LMWH during 30 days plus elastic compression stockings and early mobilization	0
Suarez MG et al., 2020³	89% CD 7% AC 4% EC	147	No anticoagulation	23%
Suarez MG et al., 2020³	89% CD 7% AC 4% EC	50	LMWH	10%

ACA – adrenocortical adenoma, ACC – adrenocortical carcinoma, CD – Cushing’s disease, CS – Cushing syndrome, EC – ectopic Cushing syndrome, GC – glucocorticoid, LMWH – Low-molecular weight heparin, VTE – venous thromboembolism events

ISSN: 1477-9560