Coagulation biomarkers and coronavirus disease 2019 phenotyping: a prospective cohort study

Thrombosis Journal

Table 3 Diagnostic parameters comparison of two in-hospital survival models derived by multivariate logistic regression and fivefold cross-validation

Parameter name	Clinical predictors			Clinical + CB			Parameter difference p-value
	value	95% CI bounds		value	95% CI bounds
	value	lower	upper	value	lower	upper
Sensitivity (%)	38	26	51	57	43	69	0.020
Specificity	93	88	96	96	91	98	0.173
PPV (%)	65	47	79	81	66	91	0.054
NPV (%)	82	76	87	87	81	91	0.093
AUROC (%)	79	73	84	86	81	90	0.036
LRT +	5.5	3.9	7.7	13	9.3	18	< 0.001
LRT-	0.67	0.63	0.71	0.45	0.42	0.49	< 0.001

CB are the coagulation biomarkers
LRT + / LRT- are Likelihood Ratios of a positive/negative test;
PPV/NPV are positive / negative predictive values; AUROC is the area under ROC curve

ISSN: 1477-9560