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Table 2 Comparison of patients’ data according to the Caprini risk assessment model

From: Education and clinical pharmacist-led management strategies for the risk and prophylaxis of venous thromboembolism in general surgery

Variables

Pre-education period (n = 340), n (%)

Post-education period (n = 269), n (%)

Intervention period (n = 191), n (%)

Total (n = 800), n (%)

p1

p2

p3

Body mass index > 25 kg/m2

231 (67.9)

180 (66.9)

126 (66.0)

537 (67.1)

 > 0.05

 > 0.05

 > 0.05

Major surgery

205 (60.3)

176 (65.4)

131 (68.6)

512 (64.0)

 > 0.05

 > 0.05

 > 0.05

41–60 years of age

158 (46.5)

126 (46.8)

81 (42.4)

365 (45.6)

 > 0.05

 > 0.05

 > 0.05

History of cancer

157 (46.2)

104 (38.7)

86 (45.0)

347 (43.4)

 > 0.05

 > 0.05

 > 0.05

Length of surgery over 2 h

80 (23.4)

77 (28.6)

46 (24.1)

203 (25.4)

 > 0.05

 > 0.05

 > 0.05

Smoking within the last month

85 (25.0)

70 (26.0)

45 (23.6)

200 (25.0)

 > 0.05

 > 0.05

 > 0.05

Laparoscopic surgery

81 (23.8)

62 (23.0)

50 (26.2)

193 (24.1)

 > 0.05

 > 0.05

 > 0.05

61–74 years of age

86 (25.3)

56 (20.8)

61 (31.9)

203 (25.4)

 > 0.05

0.007

 > 0.05

Minor surgery

54 (15.9)

31 (11.5)

10 (5.2)

95 (11.9)

 > 0.05

0.030

0.002

Varicose veins

41 (12.1)

29 (10.8)

20 (10.5)

90 (11.2)

 > 0.05

 > 0.05

 > 0.05

Serious infection

26 (7.6)

21 (7.8)

9 (4.7)

56 (7.0)

 > 0.05

 > 0.05

 > 0.05

Swollen legs

20 (5.8)

24 (8.9)

10 (5.2)

54 (6.8)

 > 0.05

 > 0.05

 > 0.05

Chemotherapy

28 (8.2)

14 (5.2)

6 (3.1)

48 (6.0)

 > 0.05

 > 0.05

 > 0.05

Diabetes requiring insulin

22 (6.5)

10 (3.7)

10 (5.2)

42 (5.3)

 > 0.05

 > 0.05

 > 0.05

History of unexplained stillborn

18 (5.2)

13 (4.8)

10 (5.2)

41 (5.1)

 > 0.05

 > 0.05

 > 0.05

 ≥ 75 years of age

11 (3.2)

18 (6.7)

12 (6.3)

41 (5.1)

 > 0.05

 > 0.05

 > 0.05

Family history of blood clots

13 (3.8)

13 (4.8)

7 (3.7)

33 (4.1)

 > 0.05

 > 0.05

 > 0.05

Lung disease

10 (2.9)

14 (5.2)

7 (3.7)

31 (3.9)

 > 0.05

 > 0.05

 > 0.05

Body mass index > 40 kg/m2

8 (2.4)

8 (3.0)

5 (2.6)

21 (2.6)

 > 0.05

 > 0.05

 > 0.05

History of venous thromboembolism

6 (1.8)

6 (2.2)

4 (2.1)

16 (2.0)

 > 0.05

 > 0.05

 > 0.05

Current use of birth control or hormone replacement therapy

8 (2.3)

4 (1.4)

7 (3.7)

19 (2.4)

 > 0.05

 > 0.05

 > 0.05

Confined to bed for 72 h or more

6 (1.8)

1 (0.4)

-

7 (0.8)

 > 0.05

-

-

Congestive heart failure

1 (0.3)

5 (1.9)

-

6 (0.7)

 > 0.05

-

-

Recurrent spontaneous abortion (3 or more)

4 (1.1)

1 (0.3)

1 (0.5)

6 (0.7)

 > 0.05

 > 0.05

 > 0.05

History of inflammatory bowel disease

1 (0.3)

2 (0.7)

-

3 (0.4)

 > 0.05

-

-

Blood transfusion(s)

-

3 (1.1)

-

3 (0.4)

-

-

-

Pregnant or had a baby within the last month

1 (0.5)

1 (0.6)

-

2 (0.3)

 > 0.05

-

-

Central venous access

1 (0.3)

1 (0.4)

-

2 (0.3)

 > 0.05

-

-

Lupus anticoagulant

1 (0.3)

1 (0.4)

-

2 (0.3)

 > 0.05

-

 

Human Immunodeficiency Virus infection

-

1 (0.4)

1 (0.5)

2 (0.3)

-

 > 0.05

-

Inherited thrombophilia

2 (0.6)

-

-

2 (0.3)

-

-

-

Factor V Leiden mutation

1 (0.3)

-

2 (1.0)

3 (0.4)

-

-

-

On bed rest or restricted mobility, including a removable leg brace for less than 72 h

1 (0.3)

-

-

1 (0.1)

-

-

-

Antiphospholipid antibodies

1 (0.3)

-

-

1 (0.1)

-

-

-

Total Score Category

 0 (very low risk)

-

-

-

-

-

-

-

 1–2 (low risk)

28 (8.2)

11 (4.1)

3 (1.6)

42 (5.3)

0.056

0.169

0.001

 3–4 (moderate risk)

73 (21.5)

72 (26.8)

51 (26.7)

196 (24.5)

0.128

0.988

0.217

  > 5 (high risk)

239 (70.3)

186 (69.1)

137 (71.7)

562 (70.2)

0.759

0.551

0.633

  1. p1: P value between pre-training and post-training period
  2. p2: p value between post-training and the clinical pharmacist-intervention period
  3. p3: p value between pre-training and the clinical pharmacist-intervention period