Fig. 4

Fibrinolysis perturbation and elevation of DAMP levels are associated with fatal outcomes. Relationships between in-hospital death and thrombocytopenia, thrombin-antithrombin complex (TAT) elevation, alpha2-plasmin inhibitor (α2-PI) depression, plasmin-α2-PI complex (PIC) elevation, plasminogen activator inhibitor-1 (PAI-1) elevation, histone H3 elevation, high mobility group box 1 protein (HMGB1) elevation, and Injury Severity Score (ISS) levels in patients with severe trauma at admission, 6 h, 12 h, day 2, and day 3 are shown. The predictive performance for in-hospital death is color-coded according to the area under the curve (AUC) of the receiver operating characteristics curve, with deep purple colors indicating high predictive performance. *P < 0.05. **P < 0.01