Fig. 2

The association between anti-Factor Xa and death, thromboembolism, bleeding and major bleeding. Red lines represent peak values, blue lines represent trough values, and the shaded area represents 95% confidence intervals. The figures illustrate anti-Factor Xa values when summarized as minimum values during intensive care (153 peak values and 300 trough values), median values during the first 14 days of intensive care (126 peak values and 266 trough values), and maximum values during intensive care (153 peak values and 300 trough values). For peak values, minimum, median and maximum values were not associated with death (p = 0.33, 0.75 and 0.44). The minimum, median and maximum values were all associated with thromboembolism (p = 0.005, 0.01 and 0.001). Minimum, median and maximum anti-Factor Xa were not associated with bleeding (p = 0.74, 0.60 and 0.41) or major bleeding (p = 0.19, 0.57 and 0.22). For trough values, not minimum but median and maximum values were associated with death (p = 0.05, 0.03 and 0.002). The minimum, median and maximum values were not associated with thromboembolism (p = 0.31, 0.31 and 0.10). Not the minimum and median but the maximum value was associated with bleeding (p = 0.19, 0.57 and 0.01) or major bleeding (p = 0.63, 0.46 and 0.02)