Table 2 Results of coagulation parameters for each group of patients: prethrombotic biomarkers, and in vitro thrombin generation. Data are presented as median (min-max). The p-values of Mann-Whitney tests were considered significant when lower than 0.05 (marked as bold italic fonts). FM: fibrin monomers, PPL: procoagulant phospholipids, TG: thrombin generation, ETP: endogenous thrombin potential
HIT- N = 92 | HIT+ N = 19 | HITT- N = 9 | HITT+ N = 10 | p-value (Mann-Whitney) | ||
|---|---|---|---|---|---|---|
HIT- vs. HIT+ | HITT- vs. HITT+ | |||||
Procoag-PPL clotting time (sec) N = 105 | 51.9 (29.7–148.3) | 65.7 (43.6–93.7) | 77.3 (43.6–93.7) | 56.4 (51.4–62.2) | 0.0027 | 0.0956 |
FM test (µg/mL) N = 107 | 5.0 (5.0-150) | 6.7 (5.0-150) | 5.0 (5.0-150) | 96.7 (5.1–150) | 0.1790 | 0.0483 |
TG Test N = 108 | ||||||
Lag time (min) | 5.4 (2.6–15.9) | 10.1 (4.7–24.4) | 12.5 (5.2–24.4) | 8.3 (4.7–12.1) | 0.0001 | 0.0637 |
Peak Height (nM) | 170.5 (29.2–406.1) | 96.6 (8.2-257.2) | 96.3 (8.2–192.2) | 111.7 (52.9–257.2) | 0.0020 | 0.2416 |
Time to Peak (min) | 7.8 (4.3–19.5) | 12.9 (7.5–32.0) | 15.7 (8.2 - 32.0) | 11.2 (7.5–16.4) | < 0.0001 | 0.0971 |
ETP (nM.min) | 1095.1 (299.9–2399.8) | 801.9 (116.0–1528.4) | 670.8 (116.0–1128.2) | 945.7 (563.5–1528.4) | 0.0470 | 0.0404 |