Table 2 Multivariate analysis of thrombotic risk in current cohort
Variants | VTE | Â | First-onset of VTE | Â | Recurrent VTE | |||
|---|---|---|---|---|---|---|---|---|
Adjusted OR(95%CI) | P value | Â | Adjusted OR(95%CI) | P value | Â | Adjusted OR(95%CI) | P value | |
Gender | 0.987 (0.699–1.396) | 0.943 |  | 0.812 (0.536–1.229) | 0.325 |  | 2.491 (1.586–3.913) | 7.40 × 10− 5 |
Age | 1.021 (1.009–1.033) | 7.71 × 10− 4 |  | / | / |  | 1.038 (1.023–1.054) | 4.56 × 10− 7 |
PC R189W | 5.781 (1.501–22.262) | 0.011 |  | 0.986 (0.425–2.288) | 0.974 |  | 0.971 (0.405–2.330) | 0.947 |
PC K193del | 4.365 (1.743–10.931) | 0.002 |  | 0.867 (0.451–1.670) | 0.670 |  | 1.804 (0.923–3.526) | 0.085 |
Rare PC mutations | 84.479 (11.499–620.654) | 1.30 × 10− 5 |  | 0.623 (0.374–1.038) | 0.069 |  | 1.892 (1.103–3.246) | 0.020 |
PS mutations | 79.009 (19.111–326.631) | 1.60 × 10− 9 |  | 0.463 (0.289–0.743) | 0.001 |  | 2.112 (1.256–3.553) | 0.005 |
AT mutations | 61.318 (8.258–455.326) | 5.70 × 10− 5 |  | 0.445 (0.232–0.851) | 0.014 |  | 3.415 (1.723–6.769) | 4.33 × 10− 4 |
Other genetic mutations | 2.35 × 109 | 0.998 |  | 0.454 (0.171–1.205) | 0.113 |  | 4.556 (1.656–12.533) | 0.003 |
Acquired risk factors | 18.273 (8.516–39.210) | 8.77 × 10− 14 |  | 0.375 (0.241–0.584) | 1.40 × 10− 5 |  | 2.107 (1.300–3.414) | 0.002 |
Positive family history | / | / |  | 1.365 (0.752–2.477) | 0.307 |  | 1.731 (0.939–3.193) | 0.079 |