Table 3 Influence of two prevalent PC mutations (R189W and K193del) on VTE in Asians population

PC R189W

^Het 5/116 (4.31)

^Het 11/1,292 (0.85)

^Het 5.10 (1.7–14.8)

Taiwanese Chinese

Tsay et al. (2004) [22]

^Het 1/85 (1.2)

^Het 0/30 (0)

Japanese

Kinoshita et al. (2005) [40]

^Het 59/1,003 (5.88)

^Het 9/1,031 (0.87)

^Het 7.10 (3.50–14.39),

adjusted: 7.34 (3.61–14.94)

3.31*10^− 10,

adjusted:3.88*10^− 8

Chinese

Tang et al. (2012) [16, 32]^a

^Het 68/1,304 (5.21)

^Het 12/1,334 (0.90)

^Het 6.06 (3.26–11.25)

1.03*10^− 10

Chinese

Tang et al. (2013) [15]^a

^Het 18/184 (9.8)

^Hom 5/184 (2.7)

^Het 40/690 (5.8)

^Hom 1/690 (0.1)

^Het 1.8 (1.0–3.2)

^Hom 20.3 (2.3–173.7)

^Het 0.042

^Hom <0.001

Thai Children

Sirachainan et al. (2018) [31]

^Het 1/283(0.4)

^Het 0/868 (0)

Japanese

Tsuda et al. (2020) [35]

^Het 16/83(19.3)

^Hom 1/83 (1.2)

^Het 2/74(2.7)

^Hom 0/74 (0)

Singapore

Tsuda et al. (2020) [35]

^All 0/85 (0)

^All 0/140 (0)

South Korea

Tsuda et al. (2020) [35]

PC K193del

^Het 2/85 (2.4)

^Het 1/30 (3.3)

Japanese

Kinoshita et al. (2005) [40]

^Het 4/173 (2.3)

Japanese

Miyata et al. (2009) [13]

^Het 68/1,003 (6.78)

^Hom 1/1,003 (0.09)

^Het 25/1,031 (2.42)

^Hom 0/1,031 (0)

^Het 2.88 (1.81–4.60)

adjusted: 2.71(1.68–4.36)

^All 2.93 (1.84–4.67)

adjusted: 2.71 (1.68–4.38)

^Het 3.80*10^− 6

adjusted: 4.04*10^− 5

^All 2.59*10^− 6

adjusted: 4.59*10^− 5

Chinese

Tang et al. (2012) [32]^a

^All 85/1,304 (6.52)

^All 32/1,334 (2.40)

^All 2.84 (1.88–4. 29)

^All 2.77*10^− 7

Chinese

Tang et al. (2013) [15]^a

^All 9/100 (4.5)

^All 5/268 (0.9)

^All 5.00 (1.66–15.12)

adjusted:5.34, (1.47–19.39)

^All 0.004

adjusted: 0.011

Chinese

Wang et al. (2016) [41]

^Het 4/446 (0.9)

^Hom 2/446 (0.4)

^Het 7/968 (0.7)

^Hom 0/968 (0)

Japanese

Tsuda et al. (2020) [35]

^Het 6/83 (7.2)

^Hom 0/83 (0)

^Het 0/74 (0)

^Hom 0/74 (0)

Singapore

Tsuda et al. (2020) [35]

^Het 2/85 (2.5)

^Hom 1/85 (1.2)

^Het 1/140 (0.7)

^Hom 1/140 (0.7)

South Korea

Tsuda et al. (2020) [35]