The genetic causal relationship between type 2 diabetes, glycemic traits and venous thromboembolism, deep vein thrombosis, pulmonary embolism: a two-sample Mendelian randomization study

Table 1 Sensitivity analysis of the MR analysis results of exposure and outcome

Exposure	Outcome	Heterogeneity Test		Pleiotropy Test	MR-PRESSO
		Cochran’s Q Test (IVW)	Rucker’s Q Test (MR-Egger)	Egger Intercept (MR-Egger)	Outliers	Pleiotropy
		P value	P value	P value	Number	P value
T2D	VTE	0.548	0.684	0.259	0	0.559
FG		0.103	0.089	0.722	0	0.057
FI		0.896	0.851	0.874	0	0.890
GH		0.260	0.258	0.355	0	0.237
T2D	DVT	0.463	0.394	0.720	0	0.520
FG		0.279	0.246	0.975	0	0.255
FI		0.896	0.875	0.545	0	0.866
GH		0.144	0.120	0.635	0	0.123
T2D	PE	0.940	0.899	0.894	0	0.951
FG		0.027	0.021	0.907	0	0.063
FI		0.633	0.681	0.209	0	0.617
GH		0.678	0.707	0.257	0	0.646

MR: Mendelian randomization; T2D: Type 2 diabetes; FG: Fasting glucose; FI: Fasting insulin; GH: Glycated hemoglobin; VTE: Venous thromboembolism; DVT: Deep vein thrombosis; PE: Pulmonary embolism

ISSN: 1477-9560