Table 1 Coagulation function, anticoagulation regimen and ECMO parameters of patients in different periods
On ECMO days | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Date | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 1 | |
Month | May | June | |||||||||||||||||||
Arterial blood gases (ABG) | PH | 7.422 | 7.426 | 7.394 | 7.395 | 7.406 | 7.398 | 7.429 | 7.398 | 7.374 | 7.409 | 7.403 | 7.412 | 7.411 | 7.424 | 7.43 | 7.443 | 7.446 | 7.444 | 7.462 | 7.463 |
PO2 | 52.4 | 64.1 | 71.8 | 80.6 | 129.9 | 89.7 | 91.7 | 81 | 103.1 | 117.4 | 102 | 107.8 | 102.5 | 102.4 | 85.4 | 99.6 | 123.9 | 138.8 | 125.7 | 135.4 | |
PCO2 | 40.4 | 43.6 | 47 | 45.5 | 42.7 | 43.4 | 40.2 | 47 | 48.8 | 44.6 | 43.9 | 42 | 42.2 | 43.7 | 44.9 | 46.7 | 41.5 | 41.6 | 42.5 | 42.1 | |
Lac | 2.2 | 1.3 | 1.1 |  < 1.0 | 1.1 | 1.3 | 1.2 | ||||||||||||||
Ventilator parameters | Ventilator mode | A/C(VC) | |||||||||||||||||||
VT(mL) | 450 | ||||||||||||||||||||
FiO2 | 100% | 60% | 70% | 60% | 100% | 90% | 80% | 40% | |||||||||||||
PEEP(cmH2O) | 8 | 10 | 12 | 14 | |||||||||||||||||
Oxygenation index | 52.4 | 64.1 | 71.8 | 80.6 | 162.4 | 179.4 | 183.4 | 162 | 206.2 | 234.8 | 255 | 215.6 | 256.35 | 256 | 85.4 | 124.5 | 123.9 | 462.7 | 419 | 451.3 | |
ECMO parameter | RPM | 3380 | 3410 | 3660 | 3551 | 4000 | 4000 | 3480 | 3575 | 3575 | 3575 | 3700 | 3702 | 3705 | 3575 | 3895 | 3895 | 3170 | 3535 | 2786 | 3010 |
LPM(L/min) | 4.22 | 3.56 | 3.7 | 3.82 | 3.98 | 4.12 | 3.55 | 3.78 | 3.78 | 3.8 | 3.94 | 3.89 | 3.81 | 3.75 | 4.24 | 4.13 | 3.33 | 3.18 | 2.29 | 2.16 | |
FiO2 | 100% | 80% | 50% | 40% | 100% | 80% | 100% | 30% | |||||||||||||
Gas flow(L/min) | 2 | 3 | |||||||||||||||||||
Anticoagulation (Heparin-IU/h or Bivaludin-mg/kg/h) | Heparin 0–800 | Heparin 1000–1200 | Heparin 1000 | Heparin 1000–1200 | Heparin 1200 | Heparin 1200–1400 | Heparin 1400 | Bivaludin 0.1–0.2 | Bivaludin 0.09–0.1 | Bivaludin 0.09 | Bivaludinn 0.07–0.08 | Bivaludin 0.07 | |||||||||
Coagulation function | APTT | 28.08 | 27.77 | 29.48 | 30.48 | 27.34 | 28.2 | 30.2 | 32.2 | 31.4 | 32.47 | 31.94 | 36.9 | 31.95 | 33.76 | 43.78 | 43.8 | 41.17 | 42.42 | 38.98 | 37.73 |
ACT | 159.9 | 157.15 | 168.3 | 167.9 | 165.83 | 174.17 | 173 | 179.33 | 174.67 | 170.58 | 171.5 | 179.45 | 186.64 | 200.23 | 212.71 | 214.64 | 216.5 | 219 | 213.5 | 211 | |
Thrombin III | 78.9 | 81.9 | 82.1 | 89.2 | 92 | 92.7 | 92.4 | 97.5 | 93.9 | 87.7 | Â | 100.1 | 93.1 | 100.4 | 98.82 | 98.57 | 102.92 | 97.72 | 104.73 | 107.63 | |
D-dimer |  > 38 | 33.5 | 22.87 | 23.96 | |||||||||||||||||
Income and output | Income (ml) | 1380 | 2475 | 2218.4 | 1998.4 | 2448.4 | 3071.8 | 2300 | 2965 | 3216.8 | 2510 | 2450 | 2702 | 2230 | 2890 | 2585 | 2350 | 2842 | 2646 | 2678 | 2219 |
Output (ml) | 2030 | 2674 | 3398 | 2979 | 3097 | 2244 | 2748 | 3726 | 3057 | 2337 | 3317 | 3131 | 2784 | 3099 | 2434 | 2039 | 1919 | 2906 | 3274 | 1852 | |
SOFA | 11 | 9 | 9 | 11 | 7 | 8 | 7 | 8 | 6 | 7 | |||||||||||