Thrombosis Journal is the official journal of the Asian-Pacific Society on Thrombosis and Hemostasis.
Articles
Page 15 of 17
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Citation: Thrombosis Journal 2009 7:3
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Mild hypothermia does not attenuate platelet aggregation and may even increase ADP-stimulated platelet aggregation after clopidogrel treatment
Mild hypothermia is currently standard of care for cardiac arrest patients in many hospitals and a common belief is that hypothermia attenuates platelet aggregation. We wanted to examine the effects of clopido...
Citation: Thrombosis Journal 2009 7:2 -
Non ST-segment elevation myocardial infarction in patient with essential thrombocythemia
A 68-year-old woman presented with acute chest pain and a greatly increased platelet count. Cardiac catheterization revealed subtotal occlusion and a thrombus-like filling defect in the right coronary artery. ...
Citation: Thrombosis Journal 2009 7:1 -
Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death
Disturbed cellular cholesterol homeostasis may lead to accumulation of cholesterol in human atheroma plaques. Cellular cholesterol homeostasis is controlled by the sterol regulatory element-binding transcripti...
Citation: Thrombosis Journal 2008 6:17 -
Human activated protein C variants in a rat model of arterial thrombosis
Activated protein C (APC) inhibits coagulation by degrading activated factor V (FVa) and factor VIII (FVIIIa), protein S (PS) functioning as a cofactor to APC.
Citation: Thrombosis Journal 2008 6:16 -
Clinical factors influencing normalization of prothrombin time after stopping warfarin: a retrospective cohort study
Anticoagulation with warfarin should be stopped 4–6 days before invasive procedures to avoid bleeding complications. Despite this routine, some patients still have high International Normalized Ratio (INR) val...
Citation: Thrombosis Journal 2008 6:15 -
A new method to determine tissue specific tissue factor thrombomodulin activities: endotoxin and particulate air pollution induced disbalance
Increase in tissue factor (TF) and loss in thrombomodulin (TM) antigen levels has been described in various inflammatory disorders. The functional consequences of such changes in antigen concentrations in the ...
Citation: Thrombosis Journal 2008 6:14 -
Prevention and treatment of venous thromboembolism with low-molecular-weight heparins: Clinical implications of the recent European guidelines
Venous thromboembolism (VTE) is an important cause of avoidable morbidity and mortality. However, routine prophylaxis for at-risk patients is underused. Recent guidelines issued by an international consensus g...
Citation: Thrombosis Journal 2008 6:13 -
Use of rosiglitazone before and after vascular injury in hypercholesterolemic rabbits: Assessment of neointimal formation
To analyse the effects of rosiglitazone administered at different times on neointimal formation in hypercholesterolemic rabbits following vascular injury.
Citation: Thrombosis Journal 2008 6:12 -
Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study
Although cigarette smoking is a well-established risk factor for vascular disease, the genetic mechanisms that link cigarette smoking to an increased incidence of stroke are not well understood. Genetic variat...
Citation: Thrombosis Journal 2008 6:11 -
Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism
Venous thromboembolism (VTE) and thromboembolic arterial diseases are usually considered to be distinct entities, but there is evidence to suggest that these disorders may be linked. The aim of this study was ...
Citation: Thrombosis Journal 2008 6:10 -
Successful management of acute thromboembolic disease complicated with heparin induced thrombocytopenia type II (HIT II): a case series
Heparin-induced thrombocytopenia type II (HIT II) is a rare immune-mediated complication of heparin. The diagnosis of HIT is considered in patients exposed to heparin, presenting with thrombocytopenia and thro...
Citation: Thrombosis Journal 2008 6:9 -
Venous thromboembolism prevention post neck of femur fractures – does it make a difference?
Neck of femur fractures predispose patients to venous thromboembolism (VTE). NICE has issued guideline 46 to reduce this risk through the use of antithrombic agents. We audited our department's VTE practise by...
Citation: Thrombosis Journal 2008 6:8 -
Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction
Warfarin treatment has a narrow therapeutic range, requiring meticulous monitoring and dosage titration. Individual dosage requirement has recently partly been explained by genetic variation of the warfarin me...
Citation: Thrombosis Journal 2008 6:7 -
Examining warfarin underutilization rates in patients with atrial fibrillation: Detailed chart review essential to capture contraindications to warfarin therapy
Atrial fibrillation affects an estimated 2.5 million Americans and incurs an average annual stroke risk of 4.5% per year. Despite warfarin reducing stroke risk by approximately 66%, prior studies show warfarin...
Citation: Thrombosis Journal 2008 6:6 -
The value of D-dimer in the detection of early deep-vein thrombosis after total knee arthroplasty in Asian patients: a cohort study
The relationship of D-dimer and deep-vein thrombosis (DVT) after total knee arthroplasty (TKA) remains controversial. The purpose of this study was to assess the value of D-dimer in the detection of early DVT ...
Citation: Thrombosis Journal 2008 6:5 -
Effects of rosiglitazone on contralateral iliac artery after vascular injury in hypercholesterolemic rabbits
The objective was to evaluate the effects of rosiglitazone on iliac arteries of hypercholesterolemic rabbits undergoing balloon catheter injury in the contralateral iliac arteries.
Citation: Thrombosis Journal 2008 6:4 -
Pleural mesothelioma and venous thrombosis: the eosinophilia link
Peripheral blood eosinophilia and vascular occlusions are rare occurrences in patients with pleural mesothelioma whereas eosinophilia may associate with thrombosis. We describe a patient with mesothelioma who ...
Citation: Thrombosis Journal 2008 6:3 -
Stroke in inflammatory bowel disease: a report of two cases and review of the literature
Thrombosis is a recognised complication of inflammatory bowel disease (IBD), in particular venous thrombosis. Arterial thrombosis, especially stroke is rare. There is a paucity of information regarding stroke ...
Citation: Thrombosis Journal 2008 6:2 -
Point-of-care platelet function assays demonstrate reduced responsiveness to clopidogrel, but not aspirin, in patients with Drug-Eluting Stent Thrombosis whilst on dual antiplatelet therapy
To test the hypothesis that point-of-care assays of platelet reactivity would demonstrate reduced response to antiplatelet therapy in patients who experienced Drug Eluting Stent (DES) ST whilst on dual antipla...
Citation: Thrombosis Journal 2008 6:1 -
Percutaneous mechanical thrombectomy for the treatment of acute massive pulmonary embolism: case report
To our knowledge we report the first case of percutaneous mechanical thrombectomy used for the treatment of massive pulmonary embolism in the United Kingdom. Pulmonary embolism is a common disease process but ...
Citation: Thrombosis Journal 2007 5:20 -
Effect of PlA1/A2 glycoprotein IIIa gene polymorphism on the long-term outcome after successful coronary stenting
To prospectively determine the role of platelet glycoprotein IIIa (GP IIIa) gene PlA1/PlA2 polymorphism on the long-term clinical outcome in patients with coronary artery disease undergoing coronary stenting.
Citation: Thrombosis Journal 2007 5:19 -
An unusual case of peripartum cardiomyopathy manifesting with multiple thrombo-embolic phenomena
Peripartum cardiomyopathy (PPCM) is a rare form of heart failure with a reported incidence of 1 per 3000 to 1 per 4000 live births and a fatality rate of 20%–50%. Onset is usually between the last month of pre...
Citation: Thrombosis Journal 2007 5:18 -
The 5, 10 methylenetetrahydrofolate reductase C677T mutation and risk of fetal loss: a case series and review of the literature
The true relationship between methylenetetrahydrofolate reductase C677T homozygosity and risk of recurrent spontaneous abortion is unknown, and it is unclear if women with these mutations should be anticoagula...
Citation: Thrombosis Journal 2007 5:17 -
Influenza infection and risk of acute pulmonary embolism
Influenza infections have been associated with procoagulant changes. Whether influenza infections lead to an increased risk of pulmonary embolism remains to be established.
Citation: Thrombosis Journal 2007 5:16 -
Dual antiplatelet therapy and drug eluting stents: a marriage of convenience
Citation: Thrombosis Journal 2007 5:15 -
Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications
Although a number of studies have demonstrated the influence of ABO blood group on plasma levels of von Willebrand factor (VWF), the nature of this association and its clinical importance is still largely unkn...
Citation: Thrombosis Journal 2007 5:14 -
Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood
During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of s...
Citation: Thrombosis Journal 2007 5:13 -
Combining Taipan snake venom time/Ecarin time screening with the mixing studies of conventional assays increases detection rates of lupus anticoagulants in orally anticoagulated patients
Oral anticoagulation compromises conventional lupus anticoagulant (LA) screening assays. Mixing studies can counteract the oral anticoagulant effect but the dilution reduces sensitivity and can generate false ...
Citation: Thrombosis Journal 2007 5:12 -
Antithrombotic prevention in vascular disease: bases for a new strategy in antithrombotic therapy
A tendency toward bleeding often undercuts the beneficial preventive effect of higher doses of a single antithrombotic drug or combined antithrombotic therapy. Although high doses of antithrombotic drugs may b...
Citation: Thrombosis Journal 2007 5:11 -
Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary report
Hyperhomocysteinemia has been described as a risk factor for unexplained recurrent pregnancy loss. Increased levels of homocysteine may be due to inadequate dietary intake of folate and vitamin B12 and inherit...
Citation: Thrombosis Journal 2007 5:10 -
Deep venous thrombosis in the antenatal period in a large cohort of pregnancies from western India
Deep venous thrombosis (DVT) is an important complication in the peripartal and postpartal period.
Citation: Thrombosis Journal 2007 5:9 -
Why differentiate low molecular weight heparins for venous thromboembolism?
Citation: Thrombosis Journal 2007 5:8 -
Increased platelet expression of FcGammaRIIa and its potential impact on platelet reactivity in patients with end stage renal disease
Increased platelet reactivity has been implicated in cardiovascular disease – the major cause of death in patients with end stage renal disease (ESRD). FcGammaRIIA is a component of glycoprotein VI and Ib-IX-V...
Citation: Thrombosis Journal 2007 5:7 -
Clopidogrel in Orthopaedic patients: a review of current practice in Scotland
Clopidogrel bisulfate is an antiplatelet agent used to prevent ischaemic events in patients with vascular disease. Current guidelines recommend withholding clopidogrel for 7 days pre-operatively. However these...
Citation: Thrombosis Journal 2007 5:6 -
Platelet adhesion onto immobilized fibrinogen under arterial and venous in-vitro flow conditions does not significantly differ between men and women
Gender-related differences in incidence of arterial thrombosis have been a focus of interest for years. The platelet integrin αIIbβ3 is primarily responsible for the interaction between platelets and fibrinoge...
Citation: Thrombosis Journal 2007 5:5 -
Histological composition and progression of carotid plaque
To analyse histological composition and progression of carotid plaque.
Citation: Thrombosis Journal 2007 5:4 -
Evaluation of the TEG® platelet mapping™ assay in blood donors
Monitoring of antiplatelet therapy in patients at cardiovascular risk is difficult because existing platelet function tests are too sophisticated for clinical routine. The whole blood TEG® Platelet Mapping™ assay...
Citation: Thrombosis Journal 2007 5:3 -
HPA-1 polymorphism of αIIbβ3 modulates platelet adhesion onto immobilized fibrinogen in an in-vitro flow system
Platelet adhesion and subsequent thrombus formation on a subendothelial matrix at the site of vascular damage play a crucial role in the arrest of posttraumatic bleeding but also in different pathological thro...
Citation: Thrombosis Journal 2007 5:2 -
Emergency correction of coagulation before major surgery in two elderly patients on oral anticoagulation
Recommendations for urgent reversal of oral anticoagulation with vitamin K1 antagonists are largely derived from case series employing empirical dosing regimens with vitamin K1 and prothrombin complex concentrate...
Citation: Thrombosis Journal 2007 5:1 -
Benign intracranial hypertension associated to blood coagulation derangements
Benign Intracranial Hypertension (BIH) may be caused, at least in part, by intracranial sinus thrombosis. Thrombosis is normally due to derangements in blood coagulation cascade which may predispose to abnorma...
Citation: Thrombosis Journal 2006 4:21 -
An unusual case of Behçet's disease presenting with postpartum ovarian iliac vein thrombosis and pulmonary embolism
Thrombosis of the ovarian vein is a rare complication which arises classically in the postpartum. We report a case of 24-year-old woman with a history of Behçet's disease, who presented with pelvic and thoraci...
Citation: Thrombosis Journal 2006 4:20 -
Antithrombin significantly influences platelet adhesion onto immobilized fibrinogen in an in-vitro system simulating low flow
Adhesion of platelets onto immobilized fibrinogen is of importance in initiation and development of thrombosis. According to a recent increase in evidence of a multiple biological property of antithrombin, we ...
Citation: Thrombosis Journal 2006 4:19 -
Preparation of platelet-rich plasma as a tissue adhesive for experimental transplantation in rabbits
Platelet-rich plasma (PRP) is an autologous substance with adhesive properties. We aimed at developing and testing the efficacy of a method for PRP preparation in rabbits.
Citation: Thrombosis Journal 2006 4:18 -
Outcomes of thromboprophylaxis with enoxaparin vs. unfractionated heparin in medical inpatients
Clinical trials have shown low-molecular weight heparin (LMWH) to be at least as safe and efficacious as unfractionated heparin (UFH) for preventing venous thromboembolism (VTE) in acutely-ill medical inpatients.
Citation: Thrombosis Journal 2006 4:17 -
The screening power of methylenetetrahydrofolate reductase C677T polymorphism versus plasma homocysteine concentration in patients with stenosis of the internal carotid artery
Hyperhomocysteinemia is an important and independent risk factor for vascular disease. About 35% of patients with stroke and 47% of patients with peripheral arterial disease have elevated plasma homocysteine (...
Citation: Thrombosis Journal 2006 4:16 -
Hereditary thrombophilia
Thrombophilia can be defined as a predisposition to form clots inappropriately. Thrombotic events during infancy and childhood are increasingly recognized as a significant source of mortality and morbidity. Th...
Citation: Thrombosis Journal 2006 4:15 -
Development of an in vitro model to study clot lysis activity of thrombolytic drugs
Thrombolytic drugs are widely used for the management of cerebral venous sinus thrombosis patients. Several in vitro models have been developed to study clot lytic activity of thrombolytic drugs, but all of th...
Citation: Thrombosis Journal 2006 4:14 -
Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction
The clinical response of sepsis to a systemic inflammatory infection may be complicated by disseminated intravascular coagulation or DIC. In order to experimentally study the syndrome of DIC, we aimed for a se...
Citation: Thrombosis Journal 2006 4:13 -
Soluble fibrin inhibits monocyte adherence and cytotoxicity against tumor cells: implications for cancer metastasis
Soluble fibrin (sFn) is a marker for disseminated intravascular coagulation and may have prognostic significance, especially in metastasis. However, a role for sFn in the etiology of metastatic cancer growth h...
Citation: Thrombosis Journal 2006 4:12
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