Figure 4
Effect of SMTP-7 on clot clearance in a rat pulmonary embolism model. Rats were injected intravenously with 125I-labeled plasma clots. The clearance of the clots was monitored before and after the treatments with SMTP-7 and/or scu-PA. (A) SMTP-7 (5 mg kg-1; n = 6) was administered intravenously ~20 min after the injection of 125I-labeled plasma clot. Control animals (n = 6) received saline. Radioactivity over the thorax was monitored (one of the 6 traces is shown in the left panel) and the fractional change in radioactivity was summarized (right panel). (B) SMTP-7 (5 mg kg-1), followed by 250 U kg-1 of scu-PA (Thrombolyse®), was administered intravenously ~20 min after the clot injection (n = 6). One unit of Thrombolyse® is comparable to ~60 IU of tcu-PA in fibrinolytic activity. In control animals (n = 6), scu-PA was given ~20 min after the clot injection. Arrow denotes time at which the administration was made. **, P < 0.01 compared with control by the Student's t-test with normally distributed variables.