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  1. Research

    Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant

    Measurement of edoxaban plasma concentration has been gathering attention in major orthopedic surgery patients receiving edoxaban for the prevention of venous thromboembolism (VTE).

    Makoto Ikejiri, Hideo Wada, Shine Tone, Hiroki Wakabayashi, Masahiro Hasegawa, Takeshi Matsumoto, Naoki Fujimoto, Norikazu Yamada, Masaaki Ito, Kaname Nakatani and Akihiro Sudo

    Thrombosis Journal 2017 15:27

    Published on: 12 October 2017

  2. Research

    The risk of venous thromboembolism associated with peripherally inserted central catheters in ambulant cancer patients

    Deep vein thrombosis (DVT) is a common complication of peripherally inserted central catheters (PICCs). PICCs are increasingly utilised in the management of cancer patients, a group which carries both addition...

    Daniel Jones, Kurt Wismayer, George Bozas, June Palmer, Mandi Elliott and Anthony Maraveyas

    Thrombosis Journal 2017 15:25

    Published on: 19 September 2017

  3. Research

    Identification of novel mutations in congenital afibrinogenemia patients and molecular modeling of missense mutations in Pakistani population

    Congenital afibrinogenemia (OMIM #202400) is a rare coagulation disorder that was first described in 1920. It is transmitted as an autosomal recessive trait that is characterized by absent levels of fibrinogen...

    Arshi Naz, Arijit Biswas, Tehmina Nafees Khan, Anne Goodeve, Nisar Ahmed, Nazish Saqlain, Shariq Ahmed, Ikram Din Ujjan, Tahir S Shamsi and Johannes Oldenburg

    Thrombosis Journal 2017 15:24

    Published on: 12 September 2017

  4. Case report

    Dabigatran reversal with idarucizumab in a patient undergoing heart transplantation: first European report

    Dabigatran is a direct thrombin inhibitor with a favorable effectiveness and safety profile when compared to vitamin K antagonists, both in randomized trials and real world registries of atrial fibrillation pa...

    António Tralhão, Carlos Aguiar, Jorge Ferreira, Maria José Rebocho, Emília Santos, Dinis Martins and José Pedro Neves

    Thrombosis Journal 2017 15:23

    Published on: 5 September 2017

  5. Research

    β3 phosphorylation of platelet αIIbβ3 is crucial for stability of arterial thrombus and microparticle formation in vivo

    It is well accepted that functional activity of platelet integrin αIIbβ3 is crucial for hemostasis and thrombosis. The β3 subunit of the complex undergoes tyrosine phosphorylation shown to be critical for outside...

    Weiyi Feng, Manojkumar Valiyaveettil, Tejasvi Dudiki, Ganapati H. Mahabeleshwar, Patrick Andre, Eugene A. Podrez and Tatiana V. Byzova

    Thrombosis Journal 2017 15:22

    Published on: 30 August 2017

  6. Research

    Comparison of different laboratory tests in the evaluation of hemorrhagic risk of patients using rivaroxaban in the critical care setting: diagnostic accuracy study

    Rivaroxaban is a direct oral anticoagulant designed to dispense with the necessity of laboratory monitoring. However, monitoring rivaroxaban levels is necessary in certain clinical conditions, especially in th...

    Marjorie Paris Colombini, Priscilla Bento Matos Cruz Derogis, Valdir Fernandes de Aranda, João Carlos de Campos Guerra, Nelson Hamerschlak and Cristóvão Luis Pitangueiras Mangueira

    Thrombosis Journal 2017 15:21

    Published on: 15 August 2017

  7. Case report

    Paget-Schroetter syndrome in the absence of common predisposing factors: a case report

    Paget-Schrotter Syndrome (PSS) also known as “effort thrombosis” is a form of primary thrombosis in the subclavian vein at the costoclavicular junction is usually seen in younger patients after repeated strenu...

    Ramy Ibrahim, Irina Dashkova, Myia Williams, Andrzej Kozikowski, Neeraj Abrol, Anjula Gandhi and Renee Pekmezaris

    Thrombosis Journal 2017 15:20

    Published on: 1 August 2017

  8. Research

    Awareness of venous thromboembolism and thromboprophylaxis among hospitalized patients: a cross-sectional study

    Patient awareness of venous thromboembolism (VTE) and thromboprophylaxis is essential for their safety. In this study, we evaluated patients’ awareness of VTE and their perceptions of thromboprophylaxis.

    Hind Almodaimegh, Lama Alfehaid, Nada Alsuhebany, Rami Bustami, Shmylan Alharbi, Abdulmalik Alkatheri and Abdulkareem Albekairy

    Thrombosis Journal 2017 15:19

    Published on: 19 July 2017

  9. Research

    Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel

    The effects of Ramadan fasting (RF) on clopidogrel antiplatelet inhibition were not previously investigated. The present study evaluated the influence of RF on platelet reactivity in patients with high cardiov...

    W. Bouida, H. Baccouche, M. Sassi, Z. Dridi, T. Chakroun, I. Hellara, R. Boukef, M. Hassine, F. Added, R. Razgallah, I. Khochtali and S. Nouira

    Thrombosis Journal 2017 15:15

    Published on: 2 June 2017

  10. Review

    Perioperative management of patients on direct oral anticoagulants

    Direct oral anticoagulants (DOACs) have been licensed worldwide for several years for various indications. Each year, 10–15% of patients on oral anticoagulants will undergo an invasive procedure and expert gro...

    Virginie Dubois, Anne-Sophie Dincq, Jonathan Douxfils, Brigitte Ickx, Charles-Marc Samama, Jean-Michel Dogné, Maximilien Gourdin, Bernard Chatelain, François Mullier and Sarah Lessire

    Thrombosis Journal 2017 15:14

    Published on: 15 May 2017

  11. Review

    The introduction of biosimilars of low molecular weight heparins in Europe: a critical review and reappraisal endorsed by the Italian Society for Haemostasis and Thrombosis (SISET) and the Italian Society for Angiology and Vascular Medicine (SIAPAV)

    Recently, the European Medicines Agency (EMA) authorized the introduction and marketing of Thorinane® and Inhixa®, biosimilars of the Low Molecular Weight Heparin (LMWH) enoxaparin. The authorization path is c...

    Davide Imberti, Marco Marietta, Hernan Polo Friz and Claudio Cimminiello

    Thrombosis Journal 2017 15:13

    Published on: 10 May 2017

  12. Research

    The CD31 molecule: a possible neuroprotective agent in acute ischemic stroke?

    The transmembrane receptor molecule CD31 is known to have immunomodulatory functions, suggesting a possible neuroprotective effect in the context of acute ischemic stroke by restricting an over-activation of s...

    Tobias Boeckh-Behrens, Justus Kleine, Johannes Kaesmacher, Claus Zimmer, Lucas Schirmer, Sophie Simon and Holger Poppert

    Thrombosis Journal 2017 15:11

    Published on: 13 April 2017

  13. Research

    Impact of blood hypercoagulability on in vitro fertilization outcomes: a prospective longitudinal observational study

    Blood coagulation plays a crucial role in the blastocyst implantation process and its alteration may be related to in vitro fertilization (IVF) failure. We conducted a prospective observational longitudinal st...

    Grigoris T. Gerotziafas, Patrick Van Dreden, Emmanuelle Mathieu d’Argent, Eleftheria Lefkou, Matthieu Grusse, Marjorie Comtet, Rabiatou Sangare, Hela Ketatni, Annette K. Larsen and Ismail Elalamy

    Thrombosis Journal 2017 15:9

    Published on: 28 March 2017

  14. Case report

    A case of pulmonary thromboembolism due to coagulation factor V Leiden in Japan ~ usefulness of next generation sequencing~

    Because the venous thromboembolisms (VTEs) due to the coagulation factor V R506Q (FV Leiden) mutation is often seen in Caucasians, the VTE onset in Japan has not been reported.

    Daisuke Sueta, Miwa Ito, Mitsuhiro Uchiba, Kenji Sakamoto, Eiichiro Yamamoto, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Satoru Shinriki, Seiji Hokimoto, Hirotaka Matsui and Kenichi Tsujita

    Thrombosis Journal 2017 15:8

    Published on: 14 March 2017

  15. Research

    The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor

    An increasing number of patients are treated with direct-acting oral anticoagulants (DOACs), but the optimal way to reverse the anticoagulant effect is not known. Specific antidotes are not available and proth...

    Nina Haagenrud Schultz, Hoa Thi Tuyet Tran, Stine Bjørnsen, Carola Elisabeth Henriksson, Per Morten Sandset and Pål Andre Holme

    Thrombosis Journal 2017 15:6

    Published on: 20 February 2017

  16. Case report

    Successful treatment of deep vein thrombosis caused by iliac vein compression syndrome with a single-dose direct oral anti-coagulant

    Although vein stenting is popular for treatment for venous thromboembolism due to mechanical compression, some cases are forced to avoid inserting align agents because of immunodeficiency.

    Naoya Nakashima, Daisuke Sueta, Yusuke Kanemaru, Seiji Takashio, Eiichiro Yamamoto, Shinsuke Hanatani, Hisanori Kanazawa, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Seiji Hokimoto and Kenichi Tsujita

    Thrombosis Journal 2017 15:4

    Published on: 1 February 2017

  17. Research

    Pro-coagulant activity during exercise testing in patients with coronary artery disease

    Strenuous exercise may trigger myocardial infarction through increased pro-coagulant activity. We aimed to investigate whether patients referred for exercise testing, who were found to have angiographically ve...

    Joanna Cwikiel, Ingebjorg Seljeflot, Eivind Berge, Harald Arnesen, Kristian Wachtell, Hilde Ulsaker and Arnljot Flaa

    Thrombosis Journal 2017 15:3

    Published on: 19 January 2017

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