Triple antithrombotic therapy in patients with atrial fibrillation undergoing coronary artery stenting: hovering among bleeding risk, thromboembolic events, and stent thrombosis

Menozzi, Mila; Rubboli, Andrea; Manari, Antonio; De Palma, Rossana; Grilli, Roberto

doi:10.1186/1477-9560-10-22

Table 1 Studies published in peer-reviewed journals on the antithrombotic treatment of patients on OAC undergoing PCI-S

From: Triple antithrombotic therapy in patients with atrial fibrillation undergoing coronary artery stenting: hovering among bleeding risk, thromboembolic events, and stent thrombosis

Author	Design of the study	Enrolment Years	Publication Year	Patients, n	Prevalence of AF in TT, %	DES, %	TT at discharge, %	Outcome comparisons, n	Follow up, months
Orford JL et al.[9]	R/SC	2000-2002	2004	66	39	0	100	None	1
Mattichak SJ et al.[10]	R/SC	2001	2005	40	43	0	100	Against contemporary patients on DAPT, 42	12
Khurram Z et al.[11]	R/SC	NR	2006	107	70	75	100	Against contemporary patients on DAPT, 107	7
Porter A et al.[12]	R/SC	2000-2004	2006	180	37	0	100	None	15
Lip GYH & Karpha M[13]	R/SC	2000-2005	2006	35	100	14	17	Within population	1
Karjalainen PP et al.[14]	R/MC	2003-2004	2007	239	70	42	48	Within population and against contemporary patients on DAPT, 239	12
DeEugenio D et al.[15]	R/SC	2000-2005	2007	97	60	30	100	Against contemporary patients on DAPT, 97	6
Rubboli A et al.[16]	R/SC	2002-2004	2007	49	60	0	41	Within population	1
Nguyen MC et al.[17]	P/MC^	1999-2006	2007	580	40	16	79	Within population	6
Rogacka RCA et al.[18]	R/SC	1999-2006	2008	127	59	56	100	None	21
Ruiz-Nodar JM et al.[19]	R/SC	2001-2006	2008	213	100	40	50	Within population	20
M.-Fernandez S et al.[20]	R/SC	2002-2006	2008	104	100	66	49	Within population	12
Sarafoff N et al.[21]	P/SC	2002-2007	2008	515	78	100	59	Within population	24
Maegdefessel L et al.[22]	R/SC	1999-2004	2008	159	100	NR	9	Within population	16
Rossini R et al.[23]	P/MC	2005-2006	2008	102	67	47	100	Against contemporary patients on DAPT, 102	18
Valencia J et al.[24]	P/SC	2004-2006	2008	70	68	60	64	Within population	12
Gao F et al.[25]	P/SC	2005-2008	2010	622	100	100	23	Within population	12
Sambola A et al.[26]	P/MC	2003-2006	2009	405	67	46	68	Within population	6
Gilard M et al.[27]	P/MC	2005-2006	2009	359	48	30	35	Within population	12
Hälg C et al.[28]	R/MC	2003-2004	2009	813	NR	65.9	5	Within population	36
Halbfass P et al.[29]	R/MC	2002-2006	2009	117	100	47	45	Within population	28
Helft G et al.[30]	P/MC	2006-2007	2009	50	62	14	100	None	1
Olson KL et al.[31]	R/SC	2003-2006	2009	175	23	81	100	Against contemporary patients on DAPT, 339	12
Baber J et al.[32]	R/SC	2003-2007	2009	454	53	100	100*	None*
Persson J et al.[33]	P/MC^	1997-2005	2010	1183	35	32	56	Within population	12
Uchidab Y et al.[34]	R/SC	2004-2007	2010	575	5	100	9	Within population	15
Guasch E et al.[35]	R/MC	2005-2006	2011	33	29	NR	100	Against same patients after stopping clopidogrel	922 pt/months
Jang SW et al.[36]	R/MC	2005-2007	2011	362	100	91	20	Within population	615

OAC= oral anticoagulation; PCI-S= percutaneous coronary intervention with stent implantation; AF= atrial fibrillation;
DES= drug eluting stent; TT= triple therapy; R= retrospective study; P= prospective study; SC= single center; MC= multi center; DAPT= dual anti-platelet treatment; NR= not reported. ^ post-hoc * evaluation of conventional TT vs modified TT (see text).

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ISSN: 1477-9560

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