Serial changes in the DIC score in the two groups. Data are expressed as group means ± standard deviation. The DIC score decreased over time in the treatment group (p < 0.05). The interaction between treatment and time was statistically significant (p < 0.01). The degree of decrease in the DIC score was significantly greater in the treatment group than in the control group. *p < 0.05 compared with the control group, †p < 0.05 compared with baseline.