Serial changes in AT III activity in the two groups. Data are expressed as group means ± standard deviation. There were no interaction between treatment and time (p = 0.618). Changes over time of AT III activity were not significantly different in the treatment group, and they showed a significant decrease compared with the maximum level and day 5 and 7 in the control group. *p < 0.01 compared with the control group, †p < 0.05 compared with baseline, ‡p < 0.05 compared with day 3.