Table 4 Results of traditional meta-analysis and meta-regression analyses of proportion of INR measurements in range
| Â | Â | Proportion of INR measurements in range | ||
|---|---|---|---|---|
Study-level factors | No. (%) | Unadjusted pooled mean upon subgroup analysis, % (95% CI) | Adjusted difference, % (95% CI) | p-v alue |
All study groups | 24 (100) | 56 (53 to 59) | NA | NA |
Study setting | Â | Â | Â | Â |
  AC Clinic | 5 (20.8) | 60 (58 to 62) | 6.9 (−0.02 to 15.2) | 0.13 |
  RCT | 5 (20.8) | 61 (54 to 68) | 5.6 (−0.06 to 17.0) | 0.36 |
  Community | 14 (58.3) | 54 (50 to 57) | Referent |  |
Study year | Â | Â | Â | Â |
  1990-2000 | 6 (25.0) | 54 (46 to 64) | 3.3 (−25.3 to 31.9) | 0.82 |
  2001-2007 | 13 (54.2) | 56 (54 to 59) | −2.8 (−14.8 to 9.2) | 0.65 |
  2008-2013 | 5 (20.8) | 56 (51 to 62) | Referent |  |
Self-management | Â | Â | Â | Â |
  No | 22 (91.7) | 55 (43 to 57) | −9.3 (−32.4 to 13.8) | 0.45 |
  Yes | 2 (8.3) | 69 (67 to 72) | Referent |  |
Geographic region | Â | Â | Â | Â |
  Europe/UK | 13 (54.2) | 57 (54 to 60) | −1.7 (−10.7 to 7.3) | 0.71 |
  Asia | 2 (8.3) | 56 (48 to 66) | −8.8 (−26.4 to 8.8) | 0.32 |
  Other | 0 (0) | NA | NA | NA |
  Multinational | 0 (0) | NA | NA | NA |
  North America | 9 (37.5) | 54 (48 to 62) | Referent |  |
VKA experience | Â | Â | Â | Â |
  NR/Mixed | 5 (20.8) | 51 (41 to 63) | −5.7 (−34.7 to 23.3) | 0.83 |
  No | 3 (12.5) | 63 (55 to 73) | 7.9 (−15.2 to 31.0) | 0.65 |
  Yes | 17 (70.8) | 56 (54 to 59) | Referent |  |
Duration of VKA treatment | Â | Â | Â | Â |
  ≥1 year | 17 (70.8) | 57 (54 to 60) | 9.1 (−0.5 to 18.7) | 0.09 |
  <1 year | 7 (29.2) | 53 (44 to 65) | Referent |  |