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Table 1 Bleeding events with new oral anticoagulants in dose-finding studies

From: New oral anticoagulants: are coagulation units still required?

Study drug: endpoint, bleeding Daily dose
Dabigatran[8] 50 mg × 2 150 mg × 2 300 mg 225 mg × 2
Clinically important % 2.3 4.1 4.9 5.1
Rivaroxaban[9, 10] 5 mg 10 mg 20 mg 30 mg
Major after surgery % 2.2 2.3 4.5 5.4
Edoxaban[11] 30 mg 30 mg × 2 60 60 mg × 2
Major + clinically relevant % 3.0 7.8 3.8 10.6