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Table 3 Metabolism of the TSOACs

From: The role of prothrombin complex concentrates in reversal of target specific anticoagulants

  Dabigatran Rivaroxaban Apixaban
Renal Impairment 6 fold higher exposure when CrCL 10–30 ml/min 1.6 fold higher exposure when CrCL 15-29 1.44 fold higher exposure when CrCL 15-29
Age Age > 75 = 30% increase in trough concentrations Mean AUC 1.5 fold higher in age > 65 Mean AUC 1.3 fold higher in age > 65
Hepatic Impairment N/A 2.3 fold increase exposure in Child-Pugh B N/A
Drug-drug interactions Avoid strong inhibitors or inducers of p-glycoprotein Avoid strong inhibitors of p-glycoprotein and CYP 3A4 Avoid strong inhibitors of p-glycoprotein and CYP 3A4
  1. AUC = Area under the curve CrCL = Creatinine Clearance CYP = Cytochrome P450.