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Table 4 Prothrombin complex concentrates composition a

From: The role of prothrombin complex concentrates in reversal of target specific anticoagulants

Prothrombin complex concentrate Factor levels (IU/ml) Protein levels ( IU/ml) Other
  II VII IX X C S Z ATIII Heparin
3 Factor          
 Bebulin 24-37 < 5 24-37 24-37 NA NA NO None < 0.15/IU FIX
 Profilnine NMT 150/U/100 Factor IX U NMT 35/U/100 Factor IX U 100 unit NMT 100/U/100 Factor IX U NA NA NA None None
4 Factor          
 Beriplex 20-48 10-25 20-31 22-60 22-31 17-19 Yes Yes Yes
 Cofact 30 13 23 26 4 21 Yes Yes None
 Kcentra 19-40 10-25 20-31 25-51 21-41 12-23 No Yes Yes
 Octaplex 31 16 22 24 12 24 Yes No Yes
Activated PCC          
 FEIBA* 1.3 IU/IU 0.9 IU/IU 1.4 IU/IU 1.1 IU/IU 1.1 IU/IU NA NA No No
  1. aAll concentrations are approximate and vary from one lot to another.
  2. NMT = not more than, IU = international units.
  3. *IU/IU = IU/FEIBA unit.