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Table 4 Prothrombin complex concentrates composition a

From: The role of prothrombin complex concentrates in reversal of target specific anticoagulants

Prothrombin complex concentrate

Factor levels (IU/ml)

Protein levels ( IU/ml)

Other

 

II

VII

IX

X

C

S

Z

ATIII

Heparin

3 Factor

         

 Bebulin

24-37

< 5

24-37

24-37

NA

NA

NO

None

< 0.15/IU FIX

 Profilnine

NMT 150/U/100 Factor IX U

NMT 35/U/100 Factor IX U

100 unit

NMT 100/U/100 Factor IX U

NA

NA

NA

None

None

4 Factor

         

 Beriplex

20-48

10-25

20-31

22-60

22-31

17-19

Yes

Yes

Yes

 Cofact

30

13

23

26

4

21

Yes

Yes

None

 Kcentra

19-40

10-25

20-31

25-51

21-41

12-23

No

Yes

Yes

 Octaplex

31

16

22

24

12

24

Yes

No

Yes

Activated PCC

         

 FEIBA*

1.3 IU/IU

0.9 IU/IU

1.4 IU/IU

1.1 IU/IU

1.1 IU/IU

NA

NA

No

No

  1. aAll concentrations are approximate and vary from one lot to another.
  2. NMT = not more than, IU = international units.
  3. *IU/IU = IU/FEIBA unit.