Changes of coagulation parameters after treatment with vascular targeting agent. Mice with Colo677 myeloma tumors were injected i.v. with a vascular targeting agent, consisting of the extracellular portion of tissue factor targeted to murine VCAM-1. Coagulation parameters were analyzed as described in the text. Black circles, left y-axis: TAT, ATIII, WBC. White circles, right y-axis: SF, PLT. Means and standard deviations (error bars) from groups of 3–6 mice are shown.