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Table 2 Activating effect of agonists on Time to Peak

From: Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

Assay System N-PRP plus TTP (minutes) mean ± SD
  B C D E F G H
  Saline rFVIIa 5 μg/mL p value B vs C rFVIIa 2.6 μg/mL P value B vs E rFVIIa 0.5 μg/mL P value B vs G
1. Saline 21.8 ± 3.9 14.3 ± 3.1 <0.001 15.1 ± 3.2 <0.001 16.5 ± 3.2 <0.001
2. ADP 2 μM 16.8 ± 3.5 13.4 ± 2.8 <0.01 13.8 ± 2.4 <0.01 13.9 ± 3.0 <0.01
3. Col 0.5 μg/mL 16,6 ± 3.4 12.5 ± 3.2 <0.05 13.5 ± 3.1 <0.01 13.3 ± 3.1 <0.01
4. AA 0.625 mmol/L 13.5 ± 2.8 12.0 ± 2.2 NS 12.1 ± 2.6 NS 12.2 ± 2.5 NS
5. AA 0.125 mmol/L 14.6 ± 3.5 12.7 ± 2.6 NS 13.1 ± 2.7 NS 12.9 ± 2.5 NS
  1. Parameters of TG in PRP from 29 normal volunteers. Effect of ADP, collagen (Col); sodium arachidonate (AA) and rFVIIa at different concentrations.
  2. Column B:1 vs 2 to 5 p < 0.001 for all. Column C 1 vs 4 p = 0.05
  3. Column E: 1 vs 4, 5 p < 0.01 and <0.05; Column G: 1 vs 2 to 5 p < 0.01.
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Thrombosis Journal

ISSN: 1477-9560

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