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Table 2 Activating effect of agonists on Time to Peak

From: Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

Assay System N-PRP plus

TTP (minutes) mean ± SD

 

B

C

D

E

F

G

H

 

Saline

rFVIIa 5 μg/mL

p value B vs C

rFVIIa 2.6 μg/mL

P value B vs E

rFVIIa 0.5 μg/mL

P value B vs G

1. Saline

21.8 ± 3.9

14.3 ± 3.1

<0.001

15.1 ± 3.2

<0.001

16.5 ± 3.2

<0.001

2. ADP 2 μM

16.8 ± 3.5

13.4 ± 2.8

<0.01

13.8 ± 2.4

<0.01

13.9 ± 3.0

<0.01

3. Col 0.5 μg/mL

16,6 ± 3.4

12.5 ± 3.2

<0.05

13.5 ± 3.1

<0.01

13.3 ± 3.1

<0.01

4. AA 0.625 mmol/L

13.5 ± 2.8

12.0 ± 2.2

NS

12.1 ± 2.6

NS

12.2 ± 2.5

NS

5. AA 0.125 mmol/L

14.6 ± 3.5

12.7 ± 2.6

NS

13.1 ± 2.7

NS

12.9 ± 2.5

NS

  1. Parameters of TG in PRP from 29 normal volunteers. Effect of ADP, collagen (Col); sodium arachidonate (AA) and rFVIIa at different concentrations.
  2. Column B:1 vs 2 to 5 p < 0.001 for all. Column C 1 vs 4 p = 0.05
  3. Column E: 1 vs 4, 5 p < 0.01 and <0.05; Column G: 1 vs 2 to 5 p < 0.01.
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Thrombosis Journal

ISSN: 1477-9560

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