Skip to main content

Table 4 Activating effect of agonists on Area under the curve (AUCo→ 35min ).

From: Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

Assay System N-PRP plus

AUC (nmol/L) mean ± SD

 

B

C

D

E

F

G

H

 

Saline

rFVIIa 5 μg/mL

p value B vs C

rFVIIa 2.6 μg/mL

P value B vs E

rFVIIa 0.5 μg/mL

P value B vs G

1. Saline

934 ± 431

1770 ± 411

<0.001

1661 ± 363

<0.001

1850 ± 327

<0.001

2. ADP 2 μM

1523 ± 364

1873 ± 366

<0.05

1773 ± 349

<0.05

2078 ± 437

<0.01

3. Col 0.5 μg/mL

1430 ± 470

1883 ± 433

<0.01

1766 ± 384

<0.05

2032 ± 502

<0.01

4. AA 0.625 mmol/L

1520 ± 373

1711 ± 410

NS

1726 ± 404

NS

1934 ± 408

<0.01

5. AA 0.125 mmol/L

1754 ± 374

1991 ± 372

NS

1872 ± 355

NS

2115 ± 403

<0.01

  1. Parameters of TG in PRP from 29 normal volunteers. Effect of ADP, collagen (Col); sodium arachidonate (AA) and rFVIIa at different concentrations.
  2. Column B:1 vs 2 to 5 p < 0.01 for all. Column G: 1 vs 5 p < 0.01
Back to article page

Thrombosis Journal

ISSN: 1477-9560

Contact us