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Table 4 Activating effect of agonists on Area under the curve (AUCo→ 35min ).

From: Thrombin generation by activated factor VII on platelet activated by different agonists. Extending the cell-based model of hemostasis

Assay System N-PRP plus AUC (nmol/L) mean ± SD
  B C D E F G H
  Saline rFVIIa 5 μg/mL p value B vs C rFVIIa 2.6 μg/mL P value B vs E rFVIIa 0.5 μg/mL P value B vs G
1. Saline 934 ± 431 1770 ± 411 <0.001 1661 ± 363 <0.001 1850 ± 327 <0.001
2. ADP 2 μM 1523 ± 364 1873 ± 366 <0.05 1773 ± 349 <0.05 2078 ± 437 <0.01
3. Col 0.5 μg/mL 1430 ± 470 1883 ± 433 <0.01 1766 ± 384 <0.05 2032 ± 502 <0.01
4. AA 0.625 mmol/L 1520 ± 373 1711 ± 410 NS 1726 ± 404 NS 1934 ± 408 <0.01
5. AA 0.125 mmol/L 1754 ± 374 1991 ± 372 NS 1872 ± 355 NS 2115 ± 403 <0.01
  1. Parameters of TG in PRP from 29 normal volunteers. Effect of ADP, collagen (Col); sodium arachidonate (AA) and rFVIIa at different concentrations.
  2. Column B:1 vs 2 to 5 p < 0.01 for all. Column G: 1 vs 5 p < 0.01