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Table 4 Changes in blood pressure in anesthetized piglets before and after induction of DIC by intravenous administration of endotoxin.

From: Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig

Mean Blood Pressure ± SD (mm Hg) P-Value*
Group Basal Follow-up Δ B vs. C vs. D vs.
A: Supportive care 74 ± 11 32 ± 23 -42 ± 26 0.238 0.195 0.118
B: AT 70 ± 17 25 ± 13 -45 ± 26   0.970 0.382
C: R-TPA 70 ± 15 23 ± 13 -47 ± 6    0.375
D: AT + R-TPA 65 ± 13 29 ± 4 -36 ± 14    
  1. Legend: Δ is the average change of follow-up from baseline. AT: antithrombin III (50 μg/kg bolus, and 25 μg/kg continuous intravenous infusion); R-TPA: recombinant tissue plasminogen activator (0.025 mg/kg/hr); SD: standard deviation. * P-values are based on statistical analysis of the average change (Δ) from baseline to follow-up for BP (paired t-test).