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Table 4 Changes in blood pressure in anesthetized piglets before and after induction of DIC by intravenous administration of endotoxin.

From: Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig

Mean Blood Pressure ± SD (mm Hg)

P-Value*

Group

Basal

Follow-up

Δ

B vs.

C vs.

D vs.

A: Supportive care

74 ± 11

32 ± 23

-42 ± 26

0.238

0.195

0.118

B: AT

70 ± 17

25 ± 13

-45 ± 26

 

0.970

0.382

C: R-TPA

70 ± 15

23 ± 13

-47 ± 6

  

0.375

D: AT + R-TPA

65 ± 13

29 ± 4

-36 ± 14

   
  1. Legend: Δ is the average change of follow-up from baseline. AT: antithrombin III (50 μg/kg bolus, and 25 μg/kg continuous intravenous infusion); R-TPA: recombinant tissue plasminogen activator (0.025 mg/kg/hr); SD: standard deviation. * P-values are based on statistical analysis of the average change (Δ) from baseline to follow-up for BP (paired t-test).
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Thrombosis Journal

ISSN: 1477-9560

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