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Table 6 Changes in hematocrits of anesthetized piglets before and after induction of DIC by intravenous administration of endotoxin.

From: Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig

Mean Hematocrit ± SD (%)

P-Value*

Group

Basal

Follow-up

Δ

B vs.

C vs.

D vs.

A: Supportive care

26 ± 5

21 ± 8

-5 ± 4

0.155

0.353

0.003

B: AT

28 ± 9

26 ± 9

-2 ± 7

 

0.647

0.115

C: R-TPA

32 ± 5

28 ± 8

-4 ± 7

  

0.050

D: AT + R-TPA

27 ± 5

29 ± 6

2 ± 4

   
  1. Legend: Δ is the average change of follow-up from baseline. AT: antithrombin III (50 μg/kg bolus, and 25 μg/kg continuous intravenous infusion); R-TPA: recombinant tissue plasminogen activator (0.025 mg/kg/hr); SD: standard deviation. * P-values are based on statistical analysis of the average change from baseline to follow-up for hematocrit (paired t-test).
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Thrombosis Journal

ISSN: 1477-9560

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