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Table 6 Changes in hematocrits of anesthetized piglets before and after induction of DIC by intravenous administration of endotoxin.

From: Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig

Mean Hematocrit ± SD (%) P-Value*
Group Basal Follow-up Δ B vs. C vs. D vs.
A: Supportive care 26 ± 5 21 ± 8 -5 ± 4 0.155 0.353 0.003
B: AT 28 ± 9 26 ± 9 -2 ± 7   0.647 0.115
C: R-TPA 32 ± 5 28 ± 8 -4 ± 7    0.050
D: AT + R-TPA 27 ± 5 29 ± 6 2 ± 4    
  1. Legend: Δ is the average change of follow-up from baseline. AT: antithrombin III (50 μg/kg bolus, and 25 μg/kg continuous intravenous infusion); R-TPA: recombinant tissue plasminogen activator (0.025 mg/kg/hr); SD: standard deviation. * P-values are based on statistical analysis of the average change from baseline to follow-up for hematocrit (paired t-test).