Skip to main content

Advertisement

Table 1 Major bleeding with aspirin versus bleeding with clopidogrel plus aspirin.

From: Antithrombotic prevention in vascular disease: bases for a new strategy in antithrombotic therapy

Aspirin daily dose Major bleeding NNH Single/dual therapy
  Aspirin Aspirin+ clopidogrel  
≤100 mg (%) 1.86 2.97 54/34
101–199 mg (%) 2.82 3.41 35/29
≥200 mg (%) 3.67 4.86 27/21
p = <0.0001 < 0.001  
  1. Major bleeding with aspirin versus bleeding with clopidogrel plus aspirin. Shown by NNH, bleeding risks increase with increasing aspirin dose and further increase with addition of clopidogrel to different doses of aspirin (Data from sub-study of the CURE trial [37]).
  2. NNH: Number Needed to Harm