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Table 2 Characteristics of the patients according to rate of normalization of prothrombin time, and warfarin therapy

From: Clinical factors influencing normalization of prothrombin time after stopping warfarin: a retrospective cohort study

Characteristics

Normal

Slow

All

Uni-variable p-value

Multi-variable p-value

N

188

14

202

  

Sex, males (%)

136(72)

11(79)

147(73)

n.s.

 

Age, y*

69.1(± 10.8)

(36–89)

73.4(± 13.2)

(48–93)

69.4(± 11.0)

(36–93)

0.16

0.49

BMI*

29.2(± 5.5)

(17.1–55.1)

29.0(± 4.3)

(22.2–40.1)

29.2(± 5.4)

(17.1–55.1)

n.s

 

Weekly warfarin dose, mg*

29.7(± 12.3)

(6.25–77)

23.2(± 13.7)

(8.75–57.5)

29.3(± 12.4)

(6.25–77)

0.06

0.20

Baseline INR*

2.6(± 0.5) (2.0–4.2)

3.2(± 0.6) (2.1–4.3)

2.7(± 0.5) (2.0–4.3)

0.0004

0.0021

Day of last dose warfarin* (in relation to surgery)

-6.1(± 0.5) (-8 – -5)

-6.1(± 0.3) (-7 – -6)

-6.1(± 0.5)

n.s.

 

Pre-operative creatinine, μmol/L*

104(± 34) (49–336)

120(± 41) (65–196)

105(± 35) (49–336)

0.09

0.40

Known liver disease (%)

7(3.7)

1(7.1)

8(4.0)

n.s.

 

Medication interaction score*

1.5(± 1.3) (-1 – 5)

1.4(± 1.4) (0–4)

1.5(± 1.3) (-1 – 5)

n.s.

 

Number of concomitant drugs*

7 (± 3) (0–14)

8 (± 3) (4–16)

7 (± 3) (0–16)

n.s.

 

Amiodarone medication (%)

29(15)

2(14)

31(15)

n.s.

 

Thyroid hormone treatment (%)

21(11)

2(14)

23(11)

n.s.