Table 1 Genotype distributions of VKORC1 1173 C>T, CYP2C9*2 and CYP2C9*3 polymorphisms in the investigated patients (MAF = minor allele frequency).
Genotype | Total material N = 212 | Warfarin N = 58 | ASA N = 72 | Warfarin + ASA N = 47 | ||||
|---|---|---|---|---|---|---|---|---|
Number of patients (genotype frequency in %) | MAF (%) | Number of patients (genotype frequency in %) | MAF (%) | Number of patients (genotype frequency in %) | MAF (%) | Number of Patients (genotype Frequency in %) | MAF (%) | |
VKORC1 | ||||||||
1173 C>T | 36.6 | 40.5 | 36.1 | 33.0 | ||||
CC | 85 (40.1) | 20 (34.5) | 30 (41.7) | 23 (48.9) | ||||
CT | 99 (46.7) | 29 (50.0) | 32 (44.4) | 17 (36.2) | ||||
TT | 28 (13.2) | 9 (15.5) | 10 (13.9) | 7 (14.9) | ||||
CYP2C9 | ||||||||
*1/*1 | 147 (69.3) | 40 (69.0) | 48 (66.7) | 33 (70.2) | ||||
*1/*2 | 38 (17.9) | 11.3 | 12 (20.7) | 11.2 | 10 (13.9) | 7.6 | 8 (17.0) | 17.0 |
*2/*2 | 4 (1.9) | - | - | 4 (8.5) | ||||
*1/*3 | 20 (9.4) | 5.7 | 5 (8.6) | 5.2 | 12 (16.7) | 10.4 | 2 (4.3) | 2.1 |
*3/*3 | 1 (0.5) | - | 1 (1.4) | - | ||||
*2/*3 | 2 (0.9) | 1 (1.7) | 1 (1.4) | - | ||||