Skip to main content

Advertisement

Table 2 Correlation analysis of variables and clopidogrel low response.

From: Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy?

Variables Low Responder patients*
N = 6
Intermediate plus High Responder patients*
N = 46
P value
Age 62 ± 13.2 64 ± 10.7 0.671
Male 4 (66) 35 (76) 0.472
Body mass index, kg/m2 26 ± 3.3 26 ± 4.3 0.956
Ejection fraction % 54 ± 3.7 52 ± 9.6 0.652
Hematocrit % 36.2 ± 7.8 37 ± 8 0.774
Platelet count (× 103/μL) 268 ± 124 235 ± 130 0.439
Current smoking 1 (17) 4 (87) 0.487
Diabetes 1 (17) 13 (29.5) 0.663
-Insulin dependent Diabetes 0 6 (15) 0.444
Chronic renal failure 0 2 (43) 0.772
Hypertension 3 (50) 29 (63) 0.369
Hypercholesterolemia 3 (50) 28 (61) 0.412
Statins 6 (100) 32 (70) 0.136
CYP3A4-metabolizing statins 5 (83) 23 (50) 0.134
  1. Values are expressed as means ± SDs or number (percentages) of patients.
  2. *Defined by flow cytometric evaluation of platelet activation parameters.