Figure 1

Trend in platelet function in relation to penicillin therapy. Platelet function was assessed by multiple electrode platelet aggregometry (AUC) in response to adenosine diphosphate (ADP) and arachidonic acid (AA). Intravenous penicillin therapy (12 million IU/day) was discontinued after 3 days of treatment. Colored lines indicate AUC mean values from human subjects in previous studies in response to either ADP (yellow) at baseline (naïve) and after receiving 600 mg clopidogrel [8], or AA (blue) before and after application of 500 mg acetylsalicylic acid (ASA) [9]. In the presence of penicillin, aggregatory response to ADP and AA was inhibited and MEA values were similar to normal responders to antiplatelet therapy.