Figure 2

Pro-coagulant activation of human monocytes by fibrinogen fragments D and E. The biological activity of the fibrinogen digestion fragments D and E were tested. Cells were pre-treated for 4 h under rotating conditions with fibrinogen fragments D or E (0.2 mg/mL) and the procoagulant activity of monocytes was tested. Like the entire molecule, fragment D decreased coagulation time significantly to 65% of untreated control cells (348 ± 56.9 sec) whereas fragment E had only a non-significant effect on the formation of stable monocyte clots. Results are given as mean ± SEM, n = 3.*: p < 0.05.