Hemodynamic and clot content measured at the baseline (base), immediately after dosing with clot (Dose) and at the end of the 24 hour or 5 day experiment in Sprague-Dawley (SD) or Copenhagen (Cop) strains of rats. Animals were treated with vehicle (Sham) or with pulmonary embolism (PE) injections. Values are mean ± standard error, where n = 10 in the SD and 4-5 in Cop experiments. *Significantly different from Base (RM ANOVA, t-Test). **Significantly different from Base and from Dose (RM ANOVA, t-Test).