Plasma D-dimer concentration measured before (-24 hr), and 8 hr and 24 hr after clot injection in Sprague-Dawley rats. Grey bars are the sham animals and clear bars are the PE animals. Values were pooled from the 24 hour and 5 day experiment. Values are mean ± standard error, n = 20. Star indicates a value significantly higher than the sham value at the same time point.