Model state

Mean

Sensitivity analyses

Source


Lower

Upper


Population norm

0.825

0.819

0.831

Kind 1998 [48]

PostIC bleeding

0.71

0.70

0.72

RiveroArias 2010 [44]

CTEPH

0.56

0.53

0.59

Meads 2008 [45]

Adjustments to utility norm due to modelled events

DVT

0.84

0.64

0.98

Locadia 2004 [46]

PE

0.63

0.36

0.86

Locadia 2004 [46]

EC bleeding (gastrointestinal bleeding was the disease state valued)

0.65

0.49

0.86

Locadia 2004 [46]

IC bleeding (haemorrhagic stroke was the disease state valued)

0.33

0.14

0.53

Locadia 2004 [46]

PTS (serious PTS was the disease state valued)

0.93

0.91

1.00

Lenert 1997 [47]

 Locadia et al. quoted a population norm (own health) as 0.95 (95% confidence interval [CI] 0.81–1.00) [46]. Utility values were adjusted according to this value before adjusting for UK population norm.
 Lower and upper values are estimates of 95% CIs from data presented (e.g. sample population size, n and standard deviation) in the source literature.
 The 95% CIs for DVT, PE, and EC and IC bleeding adjustments to utility norms have been assumed to equal the interquartile range because of the absence of further information and the size of the sample in Locadia et al. [46].
 For the probabilistic sensitivity analyses, the parameters above were modelled as arising from independent beta distributions with alpha and beta parameters set such that the mean is the point estimate and the lower and upper values represent the 95% CI.
 CTEPH, chronic thromboembolic pulmonary hypertension; DVT, deep vein thrombosis; EC, extracranial; IC, intracranial; PE, pulmonary embolism; PTS, postthrombotic syndrome.