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Table 1 95 % reference intervals for tissue factor stimulated ROTEM parameters in whole blood of 40 healthy volunteers using different concentrations of tPA

From: Validation of a modified thromboelastometry approach to detect changes in fibrinolytic activity

 

0 ng/mL rTPA

125 ng/mL rTPA

175 ng/mL rTPA

CT (s)

36–72a

33–75a

29–73a

MCF (mm)

52–70a

47–68a

39–66a

LOT (min)

73–120

26–49a

18–40a

LT (min)

>120

35–77a

25–57a

FS (%/min)

NA

2.5–9.8a

4.1–12.0

FSc (mm/min)

NA

1.4–5.7a

2.4–6.6a

  1. aafter normalization and transformation
  2. rTPA Recombinant tissue plasminogen activator, CT Clotting time, MCF Maximum clot firmness, LOT Lysis onset time, LT, Lysis time, FS Fibrinolysis speed, defined as the decline in %/min between the LOT and LT points thus: FS = 75/(LTmin-LOTmin), FS c Corrected fibrinolysis speed in mm/min between the LOT and LT points thus: FSc = (amplitudeLOT-amplitudeLT)/(LTmin-LOTmin)
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Thrombosis Journal

ISSN: 1477-9560

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