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Table 1 Patients’ demographics and clinical characteristics at enrollment into the International PNH Registry, Taiwan versus the rest of the world (ROW)

From: Characteristics of Taiwanese patients of PNH in the international PNH registry

Parameter Taiwan Patients (n = 63) ROW (n = 3857) p-value
Age, years, median (range) 46.0 (9, 84) 43.0 (0, 104) 0.331
Females, n (%) 31 (49.2) 2072 (53.7) 0.525
Age at disease start, years, median (range) 37.5 (8, 84) (n = 62) 34.0 (0, 90) (n = 3773) 0.483
Disease duration, years, median (range) 4.5 (0.1, 34.8) (n = 62) 3.0 (0.0, 100.4) (n = 3773) 0.890
GPI-Deficient Granulocytes, n (%) (n = 11) (n = 1619) 0.980
  < 10 % 3 (27.3) 482 (29.8)  
  > =10 % to < 50 % 1 (9.1) 317 (19.6)
  > = 50 % 7 (63.6) 820 (50.6)
LDH Ratio (xULN), median (Q1, Q3) 4.9 (1.9, 9.1) (n = 25) 2.0 (1.0, 5.2) (n = 2398) 0.005*
  > = 1.5, n (%) 20 (80.0) 1406 (58.6) 0.039*
Hemoglobin (g/L), median (Q1, Q3) 80.0 (68.0, 105.0) (n = 51) 99.0 (84.0, 118.0) (n = 2996) <0.001*
Platelets (x109/L), median (Q1, Q3) 112.0 (51.0, 186.0) (n = 51) 114.0 (51.0, 176.0) (n = 2990) 0.680
Serum Creatinine (umol/L), median (Q1, Q3) 66.3 (53.0, 97.2) (n = 36) 73.0 (61.9, 91.0) (n = 2746) 0.36
Proteinuria, n (%)    0.056
 Trace 2 (12.5) 93 (10.0)  
 1+ to 4+ 6 (37.5) 158 (16.9)
eGFR (mL/min), median (Q1, Q3) 95.8 (70.1, 116.5) (n = 36) 95.6 (73.9, 114.1) (n = 2638) 0.994
  < 30, n (%) 3 (8.3) 62 (2.4) 0.143
 30– < 60 3 (8.3) 329 (12.5)
 60– < 90 8 (22.2) 726 (27.5)
  > =90 22 (61.1) 1521 (57.7)
Neutrophils (x 109/L), median (Q1, Q3) 2.0 (1.0, 2.9) (n = 27) 1.9 (1.1, 2.9) (n = 2674) 0.696
History of Abdominal Pain, n (%) 17 (31.5) (n = 54) 943 (33.5) (n = 2817) 0.884
History of Dysphagia, n (%) 7 (13.0) (n = 54) 434 (15.4) (n = 2812) 0.848
History of Shortness of Breath, n (%) 32 (59.3) (n = 54) 1180 (41.9) (n = 2819) 0.012*
History of Erectile Dysfunction, n (%) 17 (60.7) (n = 28) 271 (23.0) (n = 1180) <0.001*
History of Fatigue, n (%) 44 (81.5) (n = 54) 2214 (78.5) (n = 2820) 0.738
History of Hemoglobinuria, n (%) 37 (68.5) (n = 54) 1288 (45.7) (n = 2816) 0.001*
History of Bone Marrow Disorder, n (%) 36 (58.1) (n = 62) 2265 (60.2) (n = 3762) 0.794
History of TE, n (%) 4 (6.7) (n = 60) 502 (13.5) (n = 3710) 0.178
History of any RBC Transfusion, n (%) 40 (67.8) (n = 59) 1816 (57.0) (n = 3185) 0.274
History of Impaired Renal Function, n (%) 7 (12.1) (n = 58) 456 (12.6) (n = 3609) >0.999
History of Pulmonary Hypertension, n (%) 0 (0.0) (n = 58) 68 (1.9) (n = 3670) 0.627
Ever Treated with Eculizumab, n (%) 25 (39.7) 1666 (43.2) 0.610
  1. *p <0.05